| Research objective:To observe the curative effect of the external application of Lishui Xiaozhang prescription and paclitaxel intraperitoneal perfusion in the treatment of digestive system cancerous ascites,and to investigate the effects of Lishui Xiaozhang prescription and paclitaxel peritoneal perfusion on ascites,abdominal circumference,symptoms of traditional Chinese medicine,quality of life and adverse reactions in patients with digestive system cancerous ascites.To establish the clinical value of the external application of Lishui Xiaozhang prescription in the treatment of gastric system cancerous ascites.Research methods:In accordance with the principle of random distribution,55 patients who met the criteria were divided into 2 groups.Twenty-eight people in the group were treated combined with Lishui Xiaozhang prescription and paclitaxel intraperitoneal perfusion and 27 were treated with intraperitoneal chemotherapy.Treatment of 1 cycle(a total of21 days),4 weeks after the last abdominal perfusion to observe and compare the patient’s abdominal water,abdominal circumference,Chinese medicine symptom score,KPS score and adverse reactions,statistical data analysis.Results:1.Curative index of abdominal water: Before treatment,the depth of ascites in the observation group was 95.89 ± 15.36 mm,and the depth of ascites in the control group was 91.52 ± 14.54 mm;After treatment,the depth of ascites was 58.79 ±22.40 mm,and the depth of ascites was 70.22±19.37 mm in the control group.In the group,ascites decreased in both groups compared to the pre-treatment,and in the group,T =-2.022,P <0.05,the difference is statistically significant,suggesting that this method is more effective than that of simple paclitaxel peritoneal irrigation.After treatment,the observation group completely eased 3 people,partially eased 13 people,stabilized 1 person,progressed 1 person,and efficient 57 %;The control group was completely relieved by 1 person,partially relieved by 5 people,stabilized by 18 people,progressed by 3 people,and the effective rate was 22 %.After Fisher’s exact probability method test,the two groups have significant statistically difference,and the observed group had higher efficiency than the control group.2.Periperitoneal changes: The anterior abdominal circumference was 103.57 ± 8.01 cm and the posterior abdominal circumference was 87.50±8.09 cm;The abdominal circumference of the control group was 100.41 ± 7.75 cm before treatment and94.48 ± 5.37 cm after treatment.Intra-group comparison of observation group,T =8.092,P< 0.01,comparison before and after treatment in the control group,T =3.344,P<0.05,The difference between the two groups before and after treatment was statistically significant,indicating that the abdominal circumference of the two groups decreased after treatment.Between the groups,the abdominal circumference of the two groups was compared after treatment,T =-3.76,P < 0.01,and the results suggested that the abdominal circumference of the treatment group was significantly reduced compared with that of the control group.3.Chinese medicine syndrome improvement situation: The most common abdominal distension,Nacha,sleep loss,short urine,and fatigue in patients with cancerous ascites were selected to calculate the syndromes points.Results After treatment,the symptoms of the two groups were improved.The observation group was 7.79±2.60 before treatment and 4.79±2.32 after treatment.The control group was 8.56±2.92 before treatment and 6.41±2.39 after treatment.After statistical analysis,T =-2.556,P <0.05,There’s a difference between the 2 groups,and the condition of TCM in the observation group improved significantly compared with that in the control group.4.Changes in quality of life: KPS score before treatment was 54.64 ± 12.90,after treatment 74.29 ± 14.51,intra-group comparison,T =-5.602,P <0.01,the difference is statistically significant.In the control group,KPS was 58.89 ± 12.51 before treatment and 65.19 ± 11.22 after treatment.In the group,T =-1.796 and P= 0.084>0.05,the difference is not statistically significant.KPS score was compared between the two groups after treatment,T = 2.595,P = 0.012 <0.05,the difference was statistically significant.Compared with the improvement in the quality of life of the two groups,the treatment group significantly improved by 15 people,improved by 7 people,stabilized by 3 people,and decreased by 3 people.The control group significantly improved by 6 people,improved by 10 people,stabilized by 5 people,and decreased by 6 people.After rank and test,Z =-2.271,P = 0.023 <0.05,indicating that the improvement of quality of life in the observation group was higher than in the control group.5.Adverse reactions: 55 patients were routinely examined before and after treatment for blood routine,liver and kidney function,and no obvious adverse reactions such as liver and kidney function damage and bone marrow inhibition were found.Of the28 patients in the treatment group,9 had mild local skin redness.There was no obvious rash,itching,and other discomfort.The safety was better.Conclusion:1.The curative effect of intraperitoneal perfusion of paclitaxel combined with Lishui xiaozhang prescription was better than that of intraperitoneal perfusion chemotherapy.2.In improving the symptoms of TCM,the combined Lishui xiaozhang prescription has a clear advantage over the treatment of cancerous ascites by simple peritoneal perfusion chemotherapy;3.Combined use of Lishui xiaozhang prescription can obviously improve the quality of life of patients with intraperitoneal perfusion chemotherapy;4.Lishui xiaozhang prescription is safe and effective,and the cost is low.It does not increase adverse reactions that combined with paclitaxel intraperitoneal perfusion chemotherapy,and it has a good safety and application value. |
PDF Full Text Request