| Objective To analyze and discuss the thyroid function of normal pregnant women in the Yellow River Delta region,to some extent,to promote and guide the diagnosis and treatment of abnormal thyroid function in pregnant women in this area,and to maintain maternal and fetal health.Method The pregnant women of different pregnancy periods from November 2015 to November 2017 in the Yellow River Delta Regional Medical Center of the Affiliated Hospital of Binzhou Medical College and the surrounding county-level medical centers were selected as research objects.The thyroid function test data of normal physical examination women of childbearing age similar to the age group of the experimental group were collected as a control group,and both subjects were screened in strict accordance with the inclusion exclusion criteria.According to the pregnancy period,the experimental components were early pregnancy(T1 group:0-12+6 weeks),middle pregnancy(T2 group:13-27+6 weeks),and late pregnancy(T3 group:28 weeks till delivery or cesarean section)The former)three groups,TO group is a normal control group.According to the inclusion exclusion criteria,2538 cases were included in the experimental group,including 714 in the T1 group,732 in the T2 group,and 1092 in the T3 group,and 702 cases were included in the control group TO.All included data were grouped using Excel spreadsheets for preliminary statistical analysis.SPSS 19.0 statistical software was used to statistically analyze and process each group of data.The analysis of the age and general conditions of the subjects included revealed no statistical difference in the ages of the groups.All the data were in normal distribution.The reference range used 95%confidence intervals in each group and was expressed as mean±standard deviation(X±S).The analysis of variance and t-test were used in each group.α=0.05 was used as the test level,with P<0.05 as statistically significant.Results The levels of TSH,FT3 and FT4 in thyroid function of control group were 2.17± 0.67mIU/L,4.95 ± 0.64pmol/L and 17.00 ± 1.44pmol/L,respectively.The levels of TSH,FT3 and FT4 in group T1 The levels of TSH,F-T3 and FT4 in the second trimester pregnancy were 1.83 ± 0.79mIU/L,3.71 ± 0.38pmol/L,14.14±0.94pmol/L and 16.09 ± 1.61 pmol/L respectively ± 0.86pmol/L.The levels of TSH,FT3 and FT4 in the third trimester of pregnancy were 2.31 ± 0.94mIU/L,3.73± 0.58pmol/L and 12.28 ± 1.66pmol/L,respectively.Comparing the data of the above groups and the same group,there was a significant difference between the two groups(P<0.05),suggesting that the results were statistically significant;At the same time,it also has some differences compared with recent studies at home and abroad.Conclusion(1)The level of thyroid function in the women of the Yellow River Delta is significantly different between the gestation period and the non-pregnancy period,as well as between different pregnancy periods.There are also differences in comparison with domestic and foreign guidelines.(2)Normal pregnancy in the Yellow River Delta Female TSH levels increase with the number of gestational weeks and reach and exceed the levels of non-pregnancy in the third trimester;FT3]evels decline as gestational weeks increase,but are still lower than late non-gestational levels in the third trimester;FT4 levels increase with gestational weeks However,it was lower,and both were lower than non-pregnant levels;(3)This study provided a basis for the normal gestational female specific thyroid function reference range in the Yellow River Delta region,and provided guidance for regular thyroid function tests in different pregnant women in the region during pregnancy.Thyroid drugs and/or iodine intake before and after pregnancy are important reference values to maintain normal thyroid function levels in women during pregnancy. |
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