Analysis Of CT Imaging,Clinical And Pathological Features Of Dual-phenotype Hepatocellular Carcinoma

Objective: To explore the correlation between CT imaging,clinical and pathological features of hepatocellular carcinoma(HCC)and its prognostic significance for recurrence and prognosis of HCC.Materials and Methods: CT images,clinical and pathological data of 97 patients who underwent hepatectomy in the First Affiliated Hospital of Guangxi Medical University in 2015 were retrospectively collected.The average CT values of liver and HCC were calculated,and the enhancement characteristics of HCC were evaluated by the ratio of CT values of HCC and liver.Chi-square test and ttest were used to analyze the correlation among CT images,clinical and pathological parameters.Kaplan-Meier method,log-rank test and Cox proportional risk model were used to analyze disease-free survival of HCC.Results: Among the 97 cases of HCC,the positive rates of CK7 and CK19 were 35.1% and 20.6% respectively.The results of correlation analysis showed a significantly higher CK19 expression rate was found in HCC with age < 47 years old(P=0.005),tumor diameter > 4 cm(P=0.016)or AFP ? 400 ng/ml(P=0.007),and a lower CT value ratio of HCC to liver in portal phase was found in CK19 positive group(P=0.024).The results of disease-free survival analysis showed that CK19 positive(P=0.013),tumor diameter > 4 cm(P=0.019),AFP ? 400 ng/ml(P=0.002)or CA199 ? 37 U/ml(P=0.020)had significantly increased risk of HCC recurrence.Conclusion: 1.CK19 positive expression,tumor diameter > 4cm,AFP ? 400ng/ml,CA199 ? 37U/ml are risk factors for recurrence of HCC,suggesting poor prognosis;2.CK19 expression in HCC is significantly correlated with age,tumor size and serum AFP level;3.CK19 expression may be also correlated with enhancement characteristics of HCC on CT images,but more studies are needed to confirm it.