| Delayed births have become an increasingly common phenomenon in China.Men over the age of 45 make the woman's pregnancy five times longer than men under the age of 25,and men over the age of 35 reduce the chances of a spouse's pregnancy by 50% within 12 months.The father's senior couple plays an important role in the fertility status,at least significantly increasing the time to reach the pregnancy.The influence of male age on semen parameters is controversial.First,there is no defined threshold for male semen parameters that change with age.Second,there is a conflict between the existing literature on data on male semen parameters.It has been reported that with the increase of age,semen parameters generally decline,and the decline in semen volume,vitality and morphology is most consistent.However,studies have shown that male age has no effect on semen parameters.Many studies have found a significant negative correlation between male age and husband and wife fertility.The success rate of artificial insemination is related to the age of men.This is a more demanding method for sperm quality and ability compared to IVF.Studies have shown that as the husband's age increases,the likelihood of pregnancy decreases.However,there are also reports that father age has no effect on the outcome of artificial insemination.The work of Chen et al.showed that in the conventional IVF cycle,the proportion of forward-moving sperm was less than 32%,which had a significant effect on fertilization rate,but had no significant effect on blastocyst formation rate,clinical pregnancy rate and early abortion rate.Coincidentally,Borges et al.reported the effect of sperm concentration on the fertilization rate of intracytoplasmic sperm injection,but had no effect on blastocyst formation rate.Miller and Smith found that,regardless of the fertilization technique used,the increase in male age affects blastocyst formation.Whether the influence of male age on semen parameters affects conventional in vitro fertilization/intracytoplasmic sperm injection and neonatal outcomes remains controversial.ObjectiveThe aim of this study was to correlate male age with semen quality and assisted reproductive technology pregnancy outcomes.The semen parameters were analyzed by the male side of the fertility center of the First Affiliated Hospital of Zhengzhou University,and the IUI/IVF/ICSI assisted pregnancy outcome was analyzed.Materials and MethodsThis study was a retrospective analysis of a total of 29805 couples who assisted in reproductive technology in the centre from January 1,2009 to December 31,2017.Firstly,the factors affecting the man's semen,such as chromosomal abnormalities and abnormal genital development,were excluded,and the semen parameters were analyzed,and then the pregnancy outcome was analyzed by excluding the age of 38 years,the normal range of BMI in Asian women and other female factors affecting pregnancy.We divided male patients and pregnant couples according to the age of the man aged 20-24,25-29,30-34,35-39 and ?40 years.The pregnancy outcomes between the groups were compared,including the clinical pregnancy rate,the live birth rate and so on.At the same time,the birth weight of newborns in different male age groups was tested for differences.Results(1)The volume of semen in the 25-29 age group was significantly higher than that in the group of 30-34 years old,35-39 years old and ?40 years old.The semen concentration in the 20-24 age group was significantly lower than that in the 30-34 age group and the ?40 age group.The proportion of fast forward movement semen in the age group?40 years was significantly lower than that in the 20-24,25-29,and 30-34 age groups.The proportion of slow forward movement semen in the 25-29 age group was significantly higher than that in the group of 30-34 years old,35-39 years old and ?40 years old.The proportion of total forward motor sperm in the 25-29 age group was significantly higher than that in the 35-39 years old and ?40 years old group.There were no other significant differences in conventional semen parameters for the 5 age groups.(2)There was no significant difference in the outcome of intrauterine insemination and the outcome of offspring in different male age groups(P>0.05).(3)There was no significant difference in the outcome of pregnancy and the outcome of offspring in different male age groups(P>0.05).ConclusionIn couples ?37 years of age,an increase in male age resulted in a significant decrease in the proportion of fast forward-moving sperm,but did not significantly affect IUI/IVF/ICSI outcomes. |
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