| Objective: To observe the prevalence of Glucose-6-phosphate Dehydrogenase(G6PD)deficiency in children in mainland China.Provide the necessary epidemiological basis for the individualized health management of children with G6 PD deficiency in major areas of China and the implementation of public health prevention measures.Method: Searched five databases before March 2019,namely China Knowledge Resources Integration,Wanfang,China Biomedical,Chongqing VIP and PubMed.For the search strategy,we used the following items: "glucose hexaphosphate dehydrogenase","glucose-6-phosphate dehydrogenase","glucose 6 phosphate dehydrogenase","G6PD","G-6-PD","g6pd","g-6-pd","children","youth","newborn","baby","investigation","screening","popular","occurrence","China" and "Chinese people".The identified studies should meet the following inclusion criteria:(1)report the prevalence of G6 PD deficiency;(2)report the survey year;(3)be diagnosed by a physician or technician;(4)in mainland China;(5)in Chinese or written in English.Exclude comments,meeting content and repeated research.The overall prevalence of G6 PD deficiency was calculated by using R version 3.5.2 and the subgroups wereevaluated.When I2 > 50%,the random effects model is chosen.For other I2 values,the fixed effect model was selected,and the odds ratio OR and the 95%confidence interval CI were estimated in subgroups grouped by gender,province,and diagnostic method.Meta-regression analysis was performed to explore the source of heterogeneity.At the same time,the prevalence graph and the depiction of the temporal trend correlation graph are performed.Results: We included 141 meta-analytical studies with 9,651,405 samples(age range: 0-16 years).The prevalence of G6 PD deficiency was 4.03% in all participants,while the G6 PD deficiency prevalence was 5.54% in men and1.51% in women.Figure 3 shows that the prevalence of male G6 PD deficiency is three times higher than that of women.The total prevalence of G6 PD deficiency in different periods was 4.18% [1991-2000],3.87% [2001-2010] and3.08% [2011-2017].The total prevalence of G6 PD deficiency in men and women at different time stages was 5.29%(male)/ 3.23%(female)[1991-2000],4.90%(male)/ 2.01%(female).2001-2010] and 2.64%(male)/ 0.73%(female)[2011-2017].The prevalence of G6 PD deficiency in southern China is higher than that in the central and northern regions,with Guangxi(5.77%),Guangdong(5.30%),and Hainan(3.21%)detecting the top three highest prevalence rates of G6 PD deficiency,while Shaanxi(0.02 %),Shandong(0.03%)and Hebei(0.05%)had the lowest detection rate.For men,G6 PD deficiency in male G6 PD deficiency in Guizhou(10.47%),Guangxi(7.69%),Guangdong(6.59%)and Hainan(4.88%)is the highest prevalence of G6 PD deficiency in male Chinese children.Female G6 PD deficiency also showed a high prevalence in Guizhou(4.31%),Guangdong(2.72%),Guangxi(2.52%)and Hainan(2.42%).Conclusion:1.The overall prevalence of G6 PD deficiency in children in mainland China is 4.03%,and the prevalence rate is relatively high.2.The geographical trend of G6 PD deficiency in children in mainland China shows that the incidence rate in the southern region is higher than that in the middle and north.Among them,the prevalence rate in Guangxi,Guangdong and Hainan is the highest,but with the increase of attention and population movement there is an increasing trend in the north central region.3.Between 1981 and 2017,the overall prevalence of G6 PD deficiency among children in mainland China remained between 4.18% and 3.08%.The overall prevalence rate in the southern region has stabilized,and the overall prevalence rate in the northern region has increased in ten years.4.Using G6 PD enzyme activity as a test method,the results showed that the prevalence of male and female populations was significantly different,and that men were three times as many as women.The incidence of women was inconsistent with Hardy-wenbery’s law of genetic balance.Low detection rate among female children... |
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