Comparative Study Of The Effects Of Thoracoscopic Segmentectomy,Thoracoscopic Lobectomy And Pulmonary Lobectomy On Lung Function And Immune Function In Early Stage Non-small Cell Lung Cancer

BackgroundLung cancer is a common malignant tumor in clinical practice,and its morbidity and mortality are high.About 80%of patients are non-small cell lung cancer,which poses a great threat to people's life safety.At present,the preferred method for clinical treatment of early non-small cell lung cancer is surgical treatment.Although the traditional thoracotomy can quickly remove the diseased lung lobe,it has a large trauma and many complications.It can also have a certain degree of impact on the body,and the prognosis is poor,and even increase the rate of tumor recurrence and metastasis.In recent years,with the continuous development of minimally invasive techniques,thoracoscopic surgery has attracted more and more attention and recognition from scholars.Thoracoscopy includes conventional lobectomy,sublobar resection(segment resection and pulmonary wedge resection),with obvious advantages such as less bleeding and light trauma.The clinical application is efficient and safe,which is conducive to the postoperative recovery of patients.The recovery of postoperative lung function and immune function has rarely been reported.Based on this,this study investigated the effects of thoracoscopic segmentectomy,thoracoscopic lobectomy and pulmonary lobectomy on lung function and immune function in patients with early stage NSCLC.The report is as follows.ObjectiveTo investigate the effect of thoracoscopic lobectomy,segmentectomy and pulmonary lobectomy on the treatment of early non-small cell lung cancer on patients'lung function and immune function.Methods215 cases of early non-small cell lung cancer diagnosed and treated in our hospital from September 2016 to February 2019 were collected and analyzed.According to different surgical methods,215 patients with early stage non-small cell lung cancer were divided into three groups:A,B and C.Group A was thoracoscopic segmentectomy group,group B was thoracoscopic lobectomy group,and group C was conventional.Pulmonary lobectomy,the basic conditions of the three groups of surgery were recorded,and the changes of lung function and immune function were compared before and after the third group.Statistical analysis was performed using SPSS.17.0 version.ANOVA and rank sum test were used to compare the differences between groups.The Bonferroni method was used to compare the effects of three procedures on lung function and immune function.ResultsAll three groups of operations were successfully completed,and they were all successfully discharged with no perioperative deaths.There was no significant difference in the preoperative conditions between the three groups(p>0.05).Compared with the three groups,the amount of bleeding and the operation time were significantly different between the groups(p<0.05).On the third day after surgery,the three groups were compared.The lung function(fev1,fvc and mvv)and immune function(cd3~+,cd4~+,cd4~+/cd8~+and nk cell level)of the group were significantly different between the groups.ConclusionsThoracoscopic segmentectomy has minimal impact on postoperative pulmonary function and immune function,and is more conducive to postoperative recovery.