Effect Of Adjuvant TACE Therapy On Early Recurrence After Hepatectomy For Hepatocellular Carcinoma

BackgroundHepatocellular carcinoma is one of the most common malignant tumors of the digestive system in the world.It has a high morbidity and mortality.The ratio of morbidity to mortality is close to 1.0.Because the onset of hepatocellular carcinoma is concealed,there are no obvious symptoms and rapid progress in the early stage,so most patients have progressed to the advanced stage at the time of diagnosis,and the treatment effect is not ideal,which seriously threatens human health.The existing effective treatment methods for liver cancer include hepatic resection,liver transplantation,local ablation,transarterial chemoembolization,radiotherapy and systemic therapy.Liver resection and liver transplantation are widely considered as the best treatment methods,due to lack of liver source,the choice of liver transplantation is limited,liver resection is the most common treatment for early and mid-stage hepatocellular carcinoma in China nowadays.Selecting appropriate hepatocellular carcinoma patients with radical hepatectomy can achieve good long-term survival rate.However,the recurrence rate after hepatectomy for hepatocellular carcinoma is high,which seriously affects the survival rate and overall quality of life of patients with liver cancer,so find effective treatment to reduce liver cancer.Early recurrence is crucial.Postoperative adjuvant therapy is gradually used in clinical practice,but its efficacy is controversial.At present,the more widely used adjuvant therapy is radiofrequency ablation and transcatheter arterial chemoembolization.This study will investigate the effects of TACE adjuvant therapy on early recurrence of liver cancer and the prognostic factors.ObjectiveTo investigate the effect of adjuvant therapy on early tumor recurrence in patients with early liver cancer after hepatectomy Methods27 patients who underwent adjuvant TACE after liver cancer resection and 44 patients who underwent liver resection for liver cancer were treated with single factor and multivariate analysis to influence the risk factors for postoperative recurrence.Subgroup analysis was performed according to the risk factors to compare the differences in postoperative recurrence rates.ResultsMost patients with liver cancer had cirrhosis,and pathological results shown that 50.7% of patients were accompanied by MVI.Multivariate outcome analysis showed that MVI and postoperative adjuvant TACE were risk factors for postoperative tumor recurrence.The tumor-free survival time of patients with the adjuvant TACE therapy group was significantly longer than that in patients who did not receive adjuvant therapy.In the MVI-positive subgroup,the tumor-free survival time of patients who underwent adjuvant therapy was significantly higher than that of the untreated group.In the MVI-negative subgroup,there was no difference in tumor-free survival between the two groups(P>0.05).Conclusions1.MVI is an independent risk factor for postoperative tumor recurrence2.After adjuvant treatment,patients have a better prognosis,longer tumor-free survival time3.Postoperative adjuvant therapy has a preventive effect on postoperative recurrence of MVI-positive liver cancer resection patients,and is ineffective for MVI-negative liver cancer resection patients.4.A single adjuvant treatment will give satisfactory results,and repeated TACE cycles may increase the incidence of complications..