Clinical Analysis Of Cystatin C In Predicting Cerebral Small Vessel Disease

ObjectiveStudies have shown that cerebral small vessel disease(CSVD)is associated with chronic renal insufficiency.Cysteine protease inhibitors(Cysc)are more effective than traditional methods of estimating renal function using creatinine.Whereas the association between plasma levels of cystatin(cysc)and CSVD has not been well studied,we investigated the association.Methods1.From January 2017 to April 2018,98 patients with cerebral small vessel disease who were hospitalized for various reasons and were diagnosed with cerebral small vessel disease by cranial MRI within 2 weeks and 134 normal subjects who underwent physical examination during the same period were recruited for the study;2.Patient clinical data,including plasma(Cysc)levels and MRI images,were collected and assessed.WMH was assessed using the Fazekas scale.The control group and patients were divided into three groups according to the severity of WMH: no WMH(Fazekas score 0),moderate(Fazekas score 2 ~ 3),and severe WMH(Fazekas score 4 ~ 6).3.This research uses SPSS software to process and analyze data.Measurement data were expressed as mean ± standard deviation(-x ± s).T-test was used.Count data were analyzed by ?2 test.One-way analysis of variance was used to test the significance of differences between groups.Spearson analysis was used for correlation analysis.Multivariate logistic regression analysis was used for risk factor analysis.OR and 95% CI were calculated.P < 0.05 was considered statistically significant.All multivariate analyses were first adjusted for age and sex(model 1)and then additionally adjusted for all variables.The probability value was 2 tails,and a P value < 0.05 was considered significant.ResultsThis study showed that the level of Cysc was increased in plasma,which could lead to the aggravation of symptoms of cSVD.In multivariate adjusted logistic analysis,elevated CysC levels were significantly associated with WMH severity,odds ratio(OR)(95% confidence interval: CI)1.081(1.041 – 1.122).Ordinal multiclass logistic regression analysis showed that patients' CysC levels were significantly associated with unadjusted WMH severity.For each 1 mg increase in Cyscs level,the odds ratio for a one-grade increase in WMH severity grade was(1.064)with a 95% confidence interval of(1.033;1.095)Conclusion1.In patients with cerebral small vessel disease,elevated Cysc is a risk factor for cerebral small vessel disease,and serum CysC levels correlate with WMH severity.Elevated Cysc levels are an independent risk factor for the development of cerebral small vessel disease.2.Patients with cerebral small vessel disease have a positive correlation with age and glycosylated hemoglobin as the severity of WMH increases.It showed an inverse correlation trend with triglyceride,HDL,LDL,and creatinine content.