Analysis Of 49 Cases Of Immune Thrombocytopenia During Pregnancy

Objective:To explore the clinical characteristics of immune thrombocytopenia(ITP)during pregnancy and its effect on parturient and neonatal.Methods:Retrospective analysis of clinical data of ITP patients during pregnancy admitted to the First Affiliated Hospital of Guangxi Medical University from January 2012 to October 2018,and analysis of the basic characteristics of ITP during pregnancy and its situation for mothers and neonates.Result:1.The pregnancy ITP maternal accounted for 1.48‰of the same period in our hospital.The history of ITP and the absence of ITP history of pregnancy ITP accounted for 48.98%and 51.02%,respectively.2.After treatment with glucocorticoid and human immunoglobulin before delivery of ITP during pregnancy,the median PLT was increased,and the difference was significant[28.00(42.45)×10~9/L vs 74.00(39.90)×10~9/L,P<0.05].The natural delivery rate and cesarean section rate were 30.61%and55.10%,respectively.3.In the gestation period,65.31%of patients with ITP showed hemorrhage,and 8.16%of patients showed visceral hemorrhage.The median amount of bleeding during childbirth was 300.00 ML,and the incidence of postpartum hemorrhage was 6.12%.The incidence of gestational diabetes is 14.29%.4.Neonatal median PLT at birth was 142.10(90.70)×10~9/L,Neonatal incidence of Neonatal immune thrombocytopenic purpura was 13.64%,and the incidence of hemorrhage complications was 15.91%.The average birth weight of newborns was 2946.02±486.39 g,and the incidence of low birth weight infants was 18.18%.5.Spearman analysis of the correlation between neonatal PLT and maternal PLT(the correlation coefficient r=0.061,P=0.721).Conclusion:1.ITP during pregnancy is a rare complication of blood disease.The delivery mode of the mother is mainly Caesarean section,and the risk of bleeding and complications is increased.2.ITP during pregnancy has a certain incidence of NITP,and the risk of neonatal hemorrhage increases.3.Newborn PLT has no relationship with mother onset of PLT.