The Value Of Study On The Auditory Pathway In Congenital Sensorineural Hearing Loss Children

Objective:Diffusion weighted imaging technique was used to study the microstructural or functional changes of important anatomic sites on auditory conduction pathway in children with congenital sensorineural hearing loss.To observe the changes of auditory pathway with age and the comparison between left and right sides in normal group.To find the imaging basis for whether early treatment such as cochlear implantation or other treatments can be conducive to the restoration of auditory speech function.Methods:Children with extremely severe CSNHL from May 2017 to November 2018in our hospital were collected as subjects,73 cases,the age ranged from 7months to 14 years old,with a median age of 3.8 years old.Compared with 29normal hearing children,the age ranged from 17 months to 14 years,with a median age of 9.8 years old.Routine MR,internal ear hydrography,3DT₁ and DTI were performed respectively.Siemens post-processing station was used to measure the partial anisotropy?FA?value and the apparent diffusion coefficient?ADC?value of bilateral transverse temporal gyrus,superior temporal gyrus,transverse temporal gyrus cortex,superior temporal gyrus cortex,auditory radiation,posterior limb of internal capsule,medial geniculate body,trapezium,superior olivary nucleus,ventral cochlear nucleus,dorsal cochlear nucleus and acoustic nerve.By comparing the FA and ADC values between the patients group and the normal group,to find out whether there was statistical significance or not between the two groups.The correlation between FA value and age in normal group and patients group were observed,and compare the values of FA between the left and right parts of the normal group for statistical significance.Independent sample t-test and Wilcoxon rank test was used to analyse whether there is statistical significance or not between the patients group and normal group.Pearson product difference correlation method was used to analyse the correlation between the patients group or normal group with age.Results:There were significant differences?P<0.05?in FA values in transverse temporal gyrus,superior temporal gyrus cortex,auditory radiation,posterior limb of internal capsule,medial geniculate body,trapezium and superior olivary nucleus between the patients group and the normal group,and there was no significant difference in other parts.There were significant differences?P<0.05?in ADC values between the patients group and the normal group in transverse temporal gyrus,superior temporal gyrus,posterior limb of internal capsule,auditory radiation and superior olivary nucleus,but there was no significant difference in other parts.In the normal group,the FA values were correlated with age in the transverse temporal gyrus,superior temporal gyrus,auditory radiation,trapezium,superior olivary nucleus and acoustic nerve,but there was no significant difference between left and right sides.The FA values of transverse temporal gyrus,superior temporal gyrus cortex,auditory radiation,posterior limb of internal capsule,trapezium and superior olive nucleus were correlated with age in the patients group.Conclusion:1?DTI can quantitatively analyze the microstructure and function of white matter fiber bundle and cortical center in auditory conduction pathway between children with sensorineural hearing loss and normal children.2?The FA values of auditory conduction pathway in children with normal hearing increased with age.3?There was no significant difference in the FA values of auditory conduction pathway between left and right sides in children with normal hearing.4?The values of FA in children with SNHL also showed an increasing trend with the increase of age.