Application Of UGRP1 To Predict The Risk Of Hypothyroidism In Patients With Graves’ Disease Treated With Iodine-131

Objective:To observe the expression of uteroglobin-related protein 1（UGRP1）in thyroid cells of patients with Graves’disease（GD）,and to study the relationship between the expression of UGRP1 in thyroid cells of patients with GD and the probability of hypothyroidism after iodine-131(¹³¹I)treatment.Methods:Thirty-eight GD patients were randomly selected for ¹³¹I treatment.The clinical information of age,height,weight,course of disease,the length of antithyroid drug（ATD）time,routine blood test before treatment,liver function examination,thyroid hormone and antibody level,radiation iodine treatment dose were recorded in detail.Before ¹³¹I treatment,each patient underwent thyroid aspiration cytology examination,and then UGRP1 in thyroid cells was detected by immunohistochemical method.According to the expression of UGRP1,the patients were divided into UGRP1 positive group（20 cases）and UGRP1 negative group（18 cases）.Thyroid function was followed up 12 weeks after ¹³¹I treatment.The incidence of hypothyroidism in UGRP1 positive group and UGRP1 negative group was calculated respectively.The relationship between age,body mass index,course of disease,the length of ATD time,routine blood test before treatment,liver function examination,thyroid antibody level,UGRP1 expression,radiation iodine treatment dose and incidence of hypothyroidism after ¹³¹I treatment in GD patients was further analyzed.Results:1.There were differences in the expression of UGRP1 in thyroid cells of GD patients.Among 38 patients,20 patients had positive expression of UGRP1 in thyroid cells,the positive rate was 52.6%,while 18 patients had negative expression of UGRP1in thyroid cells,the negative rate was 47.4%.2.There were no significant differences in age,height,weight,course of disease,the length of ATD time,routine blood test before treatment,liver function examination,thyroid hormone and antibody levels,radiation iodine treatment dose between UGRP1positive group and UGRP1 negative group before treatment.3.The thyroid function of GD patients was followed up 12 weeks after ¹³¹I treatment.The incidence of hypothyroidism after ¹³¹I treatment was 75%in UGRP1 positive group and 33%in UGRP1 negative group.There was significant difference between the two groups（P<0.01）.4.There was no significant correlation between age,height,weight,course of disease,the length of ATD time,routine blood test before treatment,liver function examination,thyroid hormone and antibody levels,radiation iodine treatment dose and the incidence of hypothyroidism after ¹³¹I treatment.There was no significant difference among the groups（P>0.05）.Conclusion:1.There are differences in the expression of UGRP1 in thyroid cells of GD patients,suggesting that the expression of UGRP1 may be closely related to the occurrence and development of GD,and its mechanism needs to be further explored.2.The risk of hypothyroidism in the positive expression group of UGRP1 was higher than that in the negative expression group,suggesting that the expression of UGRP1may be correlated with the risk of hypothyroidism in the GD patients after ¹³¹I treatment.3.There was no significant correlation between the incidence of hypothyroidism of ¹³¹I treatment and the age,height,weight,course of disease,the length of ATD time,routine blood test before treatment,liver function examination,thyroid hormone and antibody levels,radiation iodine treatment dose of GD patients.