Relationships Between The Serum Level Of ACE2 And NLR And The CAT Scores In Patients With AECOPD

ObjectiveTo investigate the relationships between the alteration of angiotensin-converting enzyme 2(ACE2),neutrophil/lymphocyte ratio(NLR)and platelet / lymphocyte ratio(PLR)before and after treatment and CAT,m MRC and SGRQ scores,and explore the clinical application significance of comprehensive assessment of combining inflammatory biomarkers with questionnaire scores in evaluating the severity of disease in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).MethodsA total of 97 AECOPD patients in our department from August 2017 to March 2018 were enrolled.According to pulmonary function,97 patients were classified into two groups:mild to moderate group(46 cases)and severe group(51cases).The serum levels of ACE2,C-reactive protein(CRP),whole blood neutrophils,lymphocytes and platelet counts were measured before and after treatment.CAT,m MRC and SGRQ were simultaneously completed.ResultsCompared to mild to moderate group,the levels of ACE2 and CRP,the value of NLR and PLR in severe group were significantly increased(P<0.05).Compared to treatment before,the levels of ACE2 and CRP,the value of NLR and PLR were significantly decreased in patients with AECOPD after treatment(P<0.05).The changes of the levels of ACE2 and CRP,the value of NLR and PLR were positively correlated with CAT,m MRC and SGRQ scores in AECOPD patients,respectively(P<0.05).ConclusionsComprehensive assessment of combining inflammatory biomarkers with questionnaire scores has a good clinical application value for assessing the severity of AECOPD,and provides a guild for the clinical treatment of AECOPD patients in the future.