| Objective Ventriculomegaly is the most common malformation in fetal central nervous system development,with a incidence of 7.03/10000,and is one of the most common congenital diseases of the central system.The etiology of hydrocephalus in children is complex and there are many classifications.With the continuous development of diagnostic technology in recent years,children can receive more personalized treatment with the help of ultrasonography,MRI,amniocentesis and other examinations.Children without other neurological disorders in ventriculomegaly are known as isolated ventriculomegaly,and it is generally believed that mild IVM will develop into asymptomatic hydrocephalus after the birth of most babies.This paper retrospectively analyzed the cases of fetal lateral ventricle dilatation,investigated the prognosis and intrauterine outcome of fetal lateral ventricle dilatation,and analyzed its risk factors.Methods A retrospective analysis was performed on 255 cases diagnosed with fetal lateral ventricular dilatation or hydrocephalus by prenatal color doppler ultrasound or magnetic resonance imaging in affiliated hospital of guilin medical college from January 2014 to January 2017,Analysis of prenatal imaging examination,and follow-up to investigate the pregnancy outcome.The prognosis of children after birth was evaluated by The WHO Child Growth Standards and Denver Development Screening Test.According to the prognosis of children,children were divided into case group and control group.Chi-square test and t-test were used to compare the rates between groups.Multivariate logistic regression was used to analyze the influencing factors of the prognosis of hydrocephalus in infants.Results After excluding the cases of loss of follow-up or incomplete information,164 pregnant women were collected,The average age of the pregnant women was(28.4±4.8)years old,and 22 cases(13.4%)of the pregnant women were 35 years old.The mean gestational weeks of fetal lateral ventricle enlargement was 26.2±3.6 weeks,and 85 cases(51.8%)were detected at < 24 weeks.Among them,62 cases(62/164,37.8%)of pregnant women chose induced labor,32 cases(32/164,19.5%)of pregnant women observed that wide lateral ventricle disappeared in intrauterine period,6 cases(6/164,3.7%)of fetal lateral ventricle decreased compared to the previous,24 cases(24/164,14.6%)of lateral ventricle width showed progress,and the remaining 40 cases(40/164,24.4%)of pediatric patients’ lateral ventricle width remained stable in prenatal period.pregnancy termination was excluded,and 102 cases were actually followed up.The fetus was followed up for 1-4 years after birth,excluding labor induction.102 cases were actually followed up.There were 12 cases of clinical symptoms,5 cases(5/102,4.9%)were surgical treatment for different reasons,3 cases(3/102,2.9%)symptoms of motor function,including 1 case of symptoms improved after rehabilitation treatment,2 cases(2/102,2.0%)in language learning difficulties or start talking slow time than their peers,1 case(1/102,1.0%)appear slow growth than their peers,1 case(1/102,1.0%)appeared slow growth than their peers and poor language skills.12 cases with poor prognosis were set as case group.According to maternal age,gestational age,gender of children,and follow-up,3 cases were selected for each child in the case group,and selected as the control group.Finally,the control group chose 48 cases.Using prognosis as a dependent variable,multivariate Logisitc regression analysis of the statistically significant factors showed that the width ratio change rate and lateral ventricle maximum were associated with fetal prognosis.Conclusion It is suggested that the fetal ventriculomegaly should be recommended for regular color Doppler ultrasound examination to measure the relevant indicators of the lateral ventricle.Lateral ventricle maximum and width ratio change rate may be the factor affecting the prognosis of children with hydrocephalus and has the value of predicting fetal prognosis. |
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