Application Of Quantitative Electroencephalogram To Analyze The Effect Of Transcranial Magnetic Stimulation On Non-dementia Vascular Cognitive Dysfunction

ObjectiveApplication of quantitative EEG signal analysis technology to explore the effect of transcranial magnetic stimulation on non-dementia vascular cognitive dysfunction.MethodsThirty patients with VCIND were randomized into a TMS treatment group and a sham stimulation group with 15 patients in each group.The TMS treatment group was stimulated by transcranial magnetic stimulation on the basis of drug treatment.The stimulation mode is the repetition rate TMS(r TMS),the stimulation point is located in the right dorsolateral prefrontal lobe(DLPFC),the frequency is 10 Hz,the stimulation intensity is 80% of the resting motion threshold,the stimulation amount is 1500 pulses/day,5 times per week.A total of 40 treatments in 8 weeks;the sham-stimulated group also performed transcranial magnetic stimulation on the basis of drug treatment.The direction of the stimulation coil was perpendicular to the skull and away from the skull,resulting in no effect stimulation,5 times a week.A total of 40 treatments for 8 weeks.A comprehensive neuropsychological assessment of both groups of subjects was performed before and at the end of the study.Resting EEG signals were collected from TMS-treated subjects before treatment,3 days after treatment,5 days after treatment,10 days after treatment,20 days after treatment,and 40 days after treatment.Resting data Collect for 10 minutes.ResultsComparison of TMS treatment group and sham stimulation group before and after treatment showed that the TMS treatment group increased the score of neurocognitive assessment scale after treatment,which was statistically significant.In the TMS treatment group,the power value after treatment with Alpha wave in the frontal,temporal,central,and occipital regions was significantly different from the pre-treatment power value,which was statistically significant.After treatment,it was found that the frequency of Alpha1 wave in the frontal and temporal regions of TMS treatment group increased,and with the increase of treatment time,the incidence of Alpha1 wave in the frontal and temporal regions of VCIND patients increased more significantly.ConclusionsThis study found that high-frequency TMS treatment can increase the frequency of Alpha1 waves in the frontal and temporal regions of VCIND patients,and increase the excitability of the cerebral cortex,thus improving the cognitive function of patients.The combination of MMSE,MOCA and other neuropsychological scales and quantitative EEG analysis can improve the accuracy of transcranial magnetic stimulation treatment and dynamically observe the changes of cerebral cortex excitability in real time.