Preparation And Characterization Of Sodium Alginate-Bioglass Composite Wound Dressing For Accelerated Full-Thickness Skin Wound Healing

Nowadays,full-thickness skin injury is a serious and thorny clinical problem,and wound dressings are urgently needed to treat severe skin defects or induce skin remodeling.The purpose of this study was to prepare bioglass(BG)and sodium alginate(SA)by freeze-drying SA-BG composite dressing to promote the healing of full-thickness skin defects.The prepared SA-BG composite dressing was characterized by scanning electron microscopy and Fourier transform infrared spectroscopy,and its water absorption was tested.In addition,the cell viability of the SA-BG composite dressing was evaluated using mouse skin fibroblasts(L929),human umbilical vein endothelial cells(HUVEC),and bone marrow mesenchymal stem cells(BMSCs).The effect of SA-BG composite dressing on wound healing was evaluated in vivo using a rat full-thickness skin defect model.This study shows that the SA-BG composite dressing is porous,has good water absorption,and has good biocompatibility.Most importantly,the SA+1% BG composite dressing was the best dressing for studying full-thickness skin defects in rats.After 15 days,the SA+1%BG composite dressing achieved nearly 100% healing rate compared with the blank group.The three composite dressings of SA+0.5%BG,SA+2%BG,SA+4%BG also showed With excellent healing results,this result provides evidence to support the great potential of sodium alginate-bioglass composite dressings for skin healing.