| To explore the pathogenesis of parotid dysfunction in patients with type 2 diabetes mellitus.Magnetic resonance imaging(MRI)diagnostic technique was used to study the imaging features of parotid gland(including the volume,signal and catheter)in diabetic patients and analyzed the relationship between fat deposition of parotid gland and clinical symptoms such as dry mouth.Fifty-nine male diabetic patients aged 40-60 years and 90 healthy volunteers were randomly selected to receive MRI in parotid gland,including T1-weighted imaging(T1WI)without contrast in transverse and coronal planes,T2-weighted imaging with fat suppression in transverse(FS-T2WI).3D T1-weighted volumetric interpolated breath-hold examination(VIBE)sequence and magnetic resonance sialograpy(MRS).The parotid gland volume,relative signal intensity(RSI)were measured,and fat classification was carried out according to the characteristics of signal.At the same time,diabetes patients and volunteers were investigated by Xerostomia questionnaire,and the correlation between questionnaire score and fat signal value was analyzed.The results of the experiment are as follows:(1)Parotid volume and catheter measurements: The mean volume of parotid gland in diabetic patients was significantly higher than that in control group(P=0.003).In addition,the number of enlarged parotid glands(That exceeding the control group's parotid gland mean value by 2 standard deviation)was 7,accounting for 11% of the total.There was no obvious dilatation and increase or decrease in the number of parotid ducts in diabetes mellitus patients,and no significant difference with the control group(P>0.05).(2)Measurement of parotid fat signal(RSI)and morphological classification of parotid adipose: The RSI of parotid gland changed with the change of fat content in diabetic patients.The RSI of T1 WI in parotid gland of diabetic group was significantly higher than that of control group(p=0.001),but the RSI of FS-T2 WI was slightly lower than that of control group(p=0.101).MRI features of parotid gland in diabetic group showed that Type II was the highest proportion,followed by type III(24 cases)and type IV(7 cases);Type I(90 cases)were found in healthy controls.(3)Correlation analysis of parotid fat signal value(RSI)and volume and dry oral questionnaire in diabetic patients: There was a close correlation between the RSI and volume of parotid gland in diabetic patients(correlation coefficient was 0.655).Moreover,there was significant correlation between RSI and dry mouth questionnaire score.The coefficient of correlation was 0.650.This study confirmed that the imaging features of parotid gland in diabetic patients were as follows:(1)The volume of parotid gland was enlarged in some patients.(2)Obvious fat deposition(including lipid or mature fat).(3)There was no significant abnormal dilation of the parotid duct.We speculate that there is a relationship between parotid lesions and lipid infiltration in diabetic patients.Lipid deposition may weaken the secretory function of salivary glands and lead to xerostomia,while it also led to hypertrophy of parotid glands in some patients. |
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