Study On Nondestructive Detection Of Blood Glucose And Imaging Based On Photoacoustic Technology

Diabetes mellitus,as a metabolic disorder characterized by hyperglycemia,is seriously harmful to human health and has become the third largest chronic non-communicable disease.As a comprehensive technique combining optical ?acoustic and signal processing technology,photoacoustic technology utilizes the advantages of choosing ultrasound as detection factors,effectively avoiding the scattering light and provides an effective way for noninvasive blood glucose measurement.Firstly,a new experimental system built with the use of microtransducer.With this systems,the general relationship between the photoacoustic signal and the concentration of the solution was validated at a large concentration.Then,the detection of the concentration of glucose solution(0-250mg/dl)at different wavelengths was completed.The experimental data were fitted and analyzed,,and an optimal wavelength which had a good fitting performance was obtained.Finally,two factors affecting photoacoustic detection are studied: temperature and flow rate.At the same concentration,the peak value of photoacoustic signal increases linearly with the increase of temperature.It is found that the error of concentration prediction increases with the increase of temperature.For the sample with the same concentration,the peak value of the excited photoacoustic signal decreases linearly with the increase of flow velocity.This also reminds us of the need to strictly control these factors in the future testing process,hoping to provide some help for the development of photoacoustic nondestructive testing of blood glucose.Because of the complex structure of human body,some blood vessels are dense,some are thick and some are thin,which will affect the actual detection results.In order to simulate the capillary and the test of the resolution system as much as possible,the carbon fibers with diameter less than 5 um were selected as the experimental samples.The peak projection maps of two or more carbon fibers were obtained,and the samples could be observed clearly from the projection maps.The geometry and position of the samples can be clearly observed from the projection.In the biological sample experiment,the abdominal subcutaneous blood vessels of mice were selected as the detection area,and the main blood vessel contours could be observed from the peak projection,which verified the feasibility of the system forvascular imaging.