Analysis Of Prognostic Factors Of Stage ⅢC Or ⅢC Epithelial Ovarian Cancer

Objective:To explore the related factors affecting the prognosis of stage ⅢC or Ⅳ epithelial ovarian cancer(EOC),and to provide reference for clinical individualized diagnosis and treatment.Methods: 1.The clinical data of 129 patients with stage Ⅲ C or Ⅳ epithelial ovarian cancer admitted to Hunan Cancer Hospital from January 2010 to December 2012 were retrospectively studied,including age of onset,clinical stage,histopathological type and grade,ascites volume,the size of residual lesions,and the number of postoperative adjuvant chemotherapy cycles.They were analyzed with the patient’s survival time.2.All statistical analysis was carried out by SPSS24.0 software.The counting data of disease characteristics were expressed by frequency(percentage),Kaplan-Meier test method was used to analyze the single factor survival of each variable,and the survival curve was plotted,and the data of disease characteristics were expressed by frequency(percentage),and the survival curve was drawn by Kaplan-Meier test method.Log-Rank test was used for comparison and multivariate.Logistic model was used for multivariate analysis to determine independent risk factors,P<0.05 was statistically significant.Result:1.Univariate analysis showed that the overall 5-year survival rate of patients with stage Ⅲ C or Ⅳ epithelial ovarian cancer was 26.7%,the prognosis of young patients(<50 years old)was better than that of older patients(≥50 years old)(P=0.042);The prognosis of stage Ⅲ C was better than that of stage Ⅳ(P=0.015);the survival time of ascites volume <1000ml was significantly longer than that of ascites volume≥1000ml(P=0.002);satisfactory cytoreductive surgery(residual lesion diameter<1cm)had a better prognosis than unsatisfactory cytoreductive surgery(residual lesion diameter≥1cm)(P=0.045);the prognosis of patients with postoperative adjuvant chemotherapy≥6 times was much better than that of <6 times(P=0.022);but the histopathological type and grade had no significant effect on the prognosis(P >0.05).2.Multivariate analysis showed that stage Ⅳ(OR=2.977,95% CI:1.289-6.875,P=0.011)and the number of postoperative chemotherapy cycles less than 6 times(OR=2.345,95% CI:1.169-4.702,P=0.016)were two independent risk factors for EOC.Conclusion: 1.The age of onset,clinical stage,ascites volume,the size of postoperative residual lesions and the number of postoperative adjuvant chemotherapy cycles are closely related to the prognosis of patients with advanced EOC,but there is no significant correlation between histopathological type and grade.2.For patients with stage IIIC or IV epithelial ovarian cancer,the later the clinical stage is,the less the number of adjuvant chemotherapy cycles is and the worse the prognosis will be.Therefore,we should try our best to diagnose and treat advanced EOC patients as early as possible,and we should strengthen timely,sufficient and standardized postoperative adjuvant chemotherapy in order to prolong the survival time of patients with advanced EOC.