Changes Of Angiopoietin And Myocardial Reperfusion In Patients With Acute ST-segment Elevation Myocardial Infarction With Primary Percutaneous Coronary Intervention

Objective:To determine changes in serum angiogenin and myocardial reperfusion in patients with ST-segment elevation acute myocardial infarction(STEMI)with primary percutaneous coronary intervention(PPCI).Methods:100 patients with STEMI who underwent PPCI were selected from the Department of Cardiovascular Medicine,the First Hospital of Shanxi Medical University.Another20 patients with negative coronary angiography(less than 10% stenosis)were selected as controls.ECG Max-ST-segment deviation(MAXSTE)and TIMI flow were classified into a good reperfusion group(60 cases),a better reperfusion group(24 cases)and poor reperfusion group(16 cases).They were analyzed for changes of serum angiopoietin 1(Ang1),angiopoietin 2(Ang2)and the relationship between the different myocardial reperfusion levels before and after PPCI.Results:1.The serum levels of Ang1 and Ang2 in the STEMI group were higher than those in the control group,and the difference was statistically significant(P < 0.05);2.The serum levels of Ang1 and Ang2 before PPCI in the STEMI group were significantly higher than those at the postoperative level,and the difference was statisticallysignificant(P < 0.05);3.The Ang1 group with good myocardial reperfusion before PPCI was higher than the poor myocardial reperfusion group and the difference was statistically significant(P < 0.05),preoperative and postoperative myocardial the Ang2 group with good reperfusion was lower than the poor myocardial perfusion group,and the difference was statistically significant(P < 0.05).Conclusion:For patients with STEMI who underwent PPCI,the increase of serum Ang1,the decrease of serum Ang2 before PPCI,and the decrease of serum Ang2 after PPCI can be used to evaluate the degree of myocardial reperfusion,it maybe have a certain predictive value.