Effects Of 2% Propofol Anesthesia On Blood Lipid Metabolism In Patients With Long-term Surgery

Objective:To investigate the effects of two concentrations of propofol on lipid metabolism in patients under general anesthesia with long-term surgery.Method:40 patients with long-term surgery from August 2018 to January 2019were selected as research subjects and were randomly devided in 2 groups.Group A:1%medium-long-chain propofol fatty emulsion was used to induct and maintain anesthesia,Group B:2%medium-long-chain propofol fatty emulsion to induct and maintain anesthesia.the concentration of total cholesterol（TC）,triglyceride（TG）,high-density lipoprotein cholesterol（HDL）,low-density lipoprotein cholesterol（LDL）,apolipoprotein A（ApoA）,apolipoprotein B（ApoB）concentration were measured before anesthesia induction（T₀）,3h after anesthesia induction（T₁）,6h after anesthesia induction（T₂）and were compared in the two groups.Result:Age,gender,BMI before treatment showed no significantly statistical differences between the 2 groups（P>0.05）.Compared with T₀,TC,HDL,LDL,ApoA and ApoB in group A decreased significantly at T₁ and T₂ with significantly statistical differences（P<0.05）,TG was increased at T₁ and T₂ with significantly statistical difference（P<0.05）.Compared with T0,TC,HDL,LDL,ApoA and ApoB of group B decreased at T₁ and T₂ with significantly statistical differences（P<0.05）.TG showed no significantly statistical difference at T₁（P>0.05）.TC,TG,HDL,LDL,ApoA,ApoB between the two groups showed no significantly statistical differences at T₀（P>0.05）.TG of group B was lower than group A at T₁ and T₂ with significantly statistical differences（P<0.05）.HDL and ApoA of group B were higher than those of group A at T₂ with significantly statistical differences（P<0.05）.Conclusions:This study shows that with the extension of anesthesia time,plasma triglyceride increases,and 2%propofol has less effect on blood lipid metabolism in patients,suggesting that 2%propofol has broader indications.