Analysis Of Related Factors For Type 2 Diabetes Mellitus Complicated With Hyperuricemia

Objective:The prevalence of diabetes which arise from the interactions of multiple genes and lifestyle factors,continues to rise worldwide causing serious health problems and imposing a substantial economic burden on societies.Meanwhile,the prevalence of hyperuricemia?HUA?is increasing.Besides,HUA is often combined with various chronic diseases,including diabetes and its chronic complications.The aim of this study was to analyze the correlation between serum uric acid and major risk factors for type 2diabetes mellitus,and provide reliable data on the prevalence of HUA in patients with type 2 diabetes mellitus and associated metabolic risk factors in those patients.Methods:1.The 1999 World Health Organization diagnostic criteria were used to diagnose diabetes.A total of 230 patients with type 2 diabetes mellitus were selected from the Department of Endocrinology in the Third Hospital of Hebei Medical University from March 2018 to August 2018,They were divided into two groups according to with or without HUA,the NUA group?n=155?and the HUA group?n=75?.2.Characteristics of study participants and human body parameters including height,weight,systolic blood pressure?SBP?,and diastolic blood pressure?DBP?were measured by the same researcher.Body mass index?BMI?was calculated as body weight?kg?/height?m?squared.3.Biochemical parameters:Fasting blood glucose?FBG?,serum Uric Acid?SUA?,serum creatinine?SCr?,total cholesterol?TC?,triglyceride?TG?,High density lipoprotein cholesterol?HDL-C?,low density lipoprotein cholesterol?LDL-C?,and hypersensitive c-reactive protein?hs-CRP?were measured.4.HbA1c and urinary A/Cr were determined by immunonephelometry?DCA2000?,Germany?.5.Statistical analysis:Statistical analysis was performed by SPSS software?version 21.0,SPSS Inc.,Chicago?.Normality data were presented as mean±standard deviation????±SD?,non-normality data were presented as median?interquartile range?.Student's t-tests,ANOVA,the chi-square test?x²test?,the Pearson correlation analysis and Spearman rank correlation analysis were performed.P value less than 0.05 was considered statistically significant.Logistic regession analysis was used to analyze the risk factors of type 2diabetes mellitus complicated with HUA.P<0.05 was defined as inclusion criteria.P>0.10 as the exclusion criteria.Results:1.BMI[27.04?3.72?kg/m² Vs 25.39?4.27?kg/m²]?DBP[89.00?20.00?mmHg Vs 86.00?18.00?mmHg]?UACR[2.80?10.10?mg/mmol Vs 1.70?3.40?mg/mmol]?hs-CRP[1.61?4.52?mg/L Vs 1.20?1.98?mg/L]?TG[2.71?2.20?mmol/L Vs 1.61?1.23?mmol/L]?SCr[71.78?25.82?umol/L Vs 59.65?18.30?umol/L]were significantly higher in HUA group than those in NUA group?P<0.05 or P<0.01?,Age[?55.60±14.40?years Vs?59.85±12.84?years],HbA_1C[7.80?2.63?%Vs 8.5?2.70?%],and HDL-C[1.15?0.23?mmol/L Vs 1.28?0.37?mmol/L]were lower in HUA group as compared to those in NUA group?P<0.05 or P<0.01?;The proportion of male in HUA group?77.3%Vs 55.5%?was higher than that in NUA group,and the proportion of consumption of alcohol was significantly higher in HUA group?49.3%Vs 34.2%?than that in NUA group,?P<0.05 or P<0.01?.There was no significant difference in cigarette smoking history,diabetes duration,,SBP,TC,LDL-C,FBG,and BUN between the two groups.2.SUA was positively correlated with BMI,DBP,TG,LDL-C,SCr,BUN,UACR and hs-CRP,and negatively correlated with age,FBG,HbA1C and HDL-C?P<0.05 or P<0.01?.There was no significant association between SUA and diabetes duration,SBP,TC.3.Logistic regression analysis showed that age??=-0.361,OR=0.697,P<0.01?,BMI??=0.465,OR=1.592,P<0.05?,SCr??=1.68,OR=5.363,P<0.001?,HbA1C??=-0.411,OR=0.663,P<0.05?,TG??=0.391,OR=1.478,P<0.05?were independent risk factors for type 2 diabetes mellitus with HUA.Conclusions:1.Type 2 diabetes mellitus patients with HUA usually accompany with chronic inflammatory.2.In patients with type 2 diabetes mellitus,HUA is closely related to obesity,dyslipidemia,hypertension,renal dysfunction,and inflammatory status.3.In patients with type 2 diabetes mellitus,the levels of SUA tends to decrease with the increase of blood glucose.4.Type 2 diabetes mellitus patients with Young age,obese/overweight,higher SCr,increased TG and lower HbA_1C have higher risk of HUA.