The Clinical Observation Of Myocardial Contrast Echocardiography In Patients With Coronary Slow Flow

Background: CSF is an angiographic finding characterized by delayed opacification of the distal vascular structures in the absence of obstructive.It is currently considered to be caused by coronary microvascular dysfunction(CMVD).Myocardial contrast echocardiography(MCE)is a new technique for the diagnosis of myocardial microcirculation perfusion developed in the past 20 years.It is a quantitative evaluation of myocardial perfusion by injecting microbubble contrast agent into the surrounding vein and applying micro-bubble backscattering signals by ultrasound technique,but its diagnostic value needs further confirmation by clinical experiments.Objective: This study aimed to observe myocardial perfusion in patients by myocardial contrast echocardiography,which can provide reference for the assessment of the condition and prognosis of coronary slow flow.Methods: From November 2017 to January 2019 admitted as a patient.Thirty-nine patients who underwent coronary angiography without significant stenosis but with CSF were enrolled in the study group(21 male,18 female,mean age 54.75±6.92);Thirty-nine patients with no significant stenosis and normal blood flow were included in the control group(17 male,22 female,mean age 57.61±10.78).MCE examination was performed within 3 days after coronary angiography,and the general clinical data,blood flow frame number,laboratory test results and MCE results were collected,and the results of the two groups were compared.Results: 1.All patients underwent myocardial contrast echocardiography without risk of adverse reaction,compared between the study group and the control group,the A value of the study group and the control group the difference was not statistically significant(14.67±5.32 dB vs 15.36±5.20 dB,P> 0.05),while the ? value and A×? value of the study group were lower than the study group,there were statistical differences between them.(1.02 ± 0.45 / s vs 2.24 ± 0.76 / s;15.20 ± 11.80 dB / s vs 34.96 ± 22.54)dB / s,P <0.01](A value: myocardial blood volume;? value: myocardial blood flow velocity;A × ?: myocardial blood flow);2.The percentage of neutrophils,neutrophil/lymphocyte ratio,red blood cell width,platelet width,and uric acid in the laboratory study group were higher than those in the control group{[(67.27±9.11)% vs(61.87±10.93)% ],[(3.07±1.14)vs(2.51±1.21)%],[(13.18±1.97)% vs(12.32±1.62)%],[(17.84±2.66)% vs(16.46±2.82)%],[(344.62±82.05)umol/L vs(295.47±85.11)umol/L],P <0.05}.Conclusion: The myocardial contrast echocardiography is safe and reliable,which can be used to quantitatively assess myocardial perfusion in patients.And can reflect the coronary microcirculation function status of patients with coronary slow flow,and can provide reference for the assessment of the condition and prognosis of coronary slow flow.