A Correlational Analysis Of Bone Mineral Density And Bone Metabolic Makers In Postmenopausal Women With Type 2 Diabetes Mellitus

Objective:To observe the correlation between bone mineral density and bone metabolic makers in postmenopausal women with type 2 diabetes mellitus.Methods:A retrospective analysis was made in 385 cases of postmenopausal women patients with type 2 diabetes mellitus.BMD of the hip,lumbar spine(L_1–4),femoral neck,Wards triangle and greater trochanter were determined by dualenergy X-ray absorptiometry（DXA）.General data such as age,Years since menopause,height,weight and duration of DM were collected.Bone metabolic markers such as PTH、BALP were determined by ChemiLuminescence method,electrochemical analysis was used for PINP、BGP andβ-CTX.According to T score,the patients were divided into three groups:osteoporosis group（n=233）,osteopenic group（n=101）and normal bone mass group（n=51）.Datas of general clinical informations,bone metabolic makers and bone mineral density etc were analyzed to identify the correlation of bone mineral density and bone metabolic makers.Results:there were no significant differences in general data among the groups,including age、menopause、duration of diabetes、BMI and HbA1c level（P>0.05）.And Ca,Mg,P and PTH among the three groups were also not significantly different（P>0.05）.Blood 25（OH）D level in the osteoporosis group was significantly different from that in the osteopenic group（P<0.05）,while there was no significant difference among the osteoporosis group、osteopenic group and the normal bone mass group（P>0.05）.The level of BGP and PINP in osteoporosis group is the highest compared with osteopenic group and normal bone mass group（P<0.05）,and there was also significant difference between the osteopenic group and the normal bone mass group（P<0.05）.Compared with the normal bone mass group,the level ofβ-CTX significantly increased in the osteoporosis group and the osteopenic group,and the differences were statistically significant（P<0.05）.Spearman correlation analysis showed that PINP,BGP andβ-CTX were negatively correlated with BMD level and that 25（OH）D was postivately correlated with BMD level.Conclusion:With the decreasing of bone density,PINP、BGP andβ-CTX increase gradually in postmenopausal women with type 2 diabetes mellitus（P<0.05）.