A Correlation Analysis Of Serum 25-hydroxy Vitamin D And Bone Metabolic Markers In Type 2 Diabetic Patients

Objective: To investigate the serum 25-hydroxy vitamin D level and its correlation with bone metabolic markers.Methods: A retrospective analysis was made in 512 cases of patients with type 2 diabetes mellitus.Datas of general clinical information,erum25-hydroxy vitamin D,blood calcium,serum phosphate,parathyroid hormone,type 1 procollagen N-terminal propeptide,?-Carboxyl terminal peptide,bone gla protein,bone alkaline phosphatase,micro-albumin creatinine ratio and bone mineral density were collected.All diabetic patients were divided into four groups according to the level of serum25-hydroxy vitamin D,including severe deficiency group(G1 group,n=129),deficiency group(G2 group,n=258),insufficiency group,(G3group,n=104),and sufficiency group(G4 group,n=21).Results: The deficiency and insufficiency of vitamin D in patients with type 2 diabetes is usually universal.The PTH,ACR,P1 NP,?-CTX and BGP levels showed a tendency to decrease with the increase of serum25-hydroxy vitamin D level,PTH in severe vitamin D deficiency groupwas the histest compared to those in deficiency group,insufficiency group and sufficiency group(P<0.05).P1NP??-CTX?BGP in severe vitamin D deficiency group were the histest compared to those in insufficiency group and sufficiency group(P < 0.05).Pearson correlation analysis showed that blood calcium,bone mineral density was positively correlated with serum 25-hydroxy vitamin D and that PTH,ACR,?-CTX,BGP,P1 NP and age were negatively correlated with serum 25-hydroxy vitamin D(P<0.05).Conclusion: The deficiency and insufficiency of vitamin D in patients with type 2 diabetes is universal phenomenon.The level of 25-(OH)D is correlated with the development of diabetic nephropathy in type 2 diabetes mellitus.Combined serum 25-hydroxy vitamin D and bone metabolism markers is helpful for the diagnosis and treatment of osteoporosis in type 2diabetes patients.