Risks Of Developing Oxygenation Impairment In The Patients With Acute Aortic Dissection

Background: Acute aortic dissection(AAD)is an acute life-threatening large vessel disease,which can cause oxygenation impairment(OI)with poor prognosis.Currently,there are no effective ways to evaluate the risks of developing OI in the patients with AAD so that it is very difficult to treat AAD precisely.Objective: To analyze the risk factors of clinical parameters in developing OI in patients with AAD.Methods: We retrospectively reviewed clinical data of the patients diagnosed with AAD from January 2012 to September 2018.The patients enrolled in this study were divided into OI group(oxygenation index<200)and control group(oxygenation index?200).The basic characteristics and laboratory examination results were retrospectively collected and statistic analysis was performed to compare the differences of clinical parameters between the two groups.Results: 150 patients were enrolled in this study and 70 patients were diagnosed with OI(46.67%).Of the basic characteristics,the patients have higher peaks of body temperature(37.88±0.64? VS 37.61±0.49?)andmore frequency of breathing(20.6±3.2 per minute VS 19.6±1.9 per minute)in OI group.The laboratory examination results indicate higher level of C reactive protein(CRP)(55.56±29.21 mg/L VS 19.84±15.90 mg/L)and lower level of serum albumin(31.86±3.99 g/L VS 35.92±5.20 g/L)in OI group compared with control group.There are significant differences in higher peaks of body temperature,frequency of breathing and level of CRP and albumin between the two groups.Conclusion: This study indicates that the patients with higher level of CRP,lower level of albumin,higher peaks of body temperature,and more frequency of breathing may be predictors in developing OI in patients with AAD.