| Objectives By comparing the efficacy of MECT combined with second-generation antipsychotic treatment in patients with schizophrenia,it provides a reliable basis for clinical treatment of acute phase of schizophrenia.Methods According to the method of clinical trial research,45 subjects were divided into three groups according to the order of admission,which were olanzapine and risperidone combined with MECT group(control group),olanzapine combined with MECT group(olanzapine treatment group).),risperidone combined with MECT group(risperidone treatment group),the three groups received corresponding treatment.The PANSS score and the Mo Ca scale were scored before treatment,and the PANSS score Mo Ca score and TESS score were performed at the 2nd,4th,and 8th week of the treatment.The differences between groups and groups before and after treatment were compared.Six times of MECT is a course of treatment for patients with acute schizophrenia.Do MECT every Monday,Wednesday,and Friday for a total of 6 treatments.Results 1 The total effective rate was compared after the 8th week of treatment.In the experimental group,2 cases were cured,10 cases were significant,the total effective rate was 80.0%,and 1 case was cured in the control group,9 cases were significant,and the total effective rate was 66.6%.Group 2 was cured in 2 cases,9 cases were significant,and the total effective rate was 73.3%.The analysis of variance showed that the difference of the three groups was not statistically significant(P>0.05).2 PANSS scores showed that the PANSS scale treatment scores of the three groups were significantly lower than those before treatment(P<0.05).3 At the 2nd and 4th weekends of treatment,the PANSS positive symptom scale of the experimental group was lower than the two control groups,and the difference was statistically significant(P<0.05),but at the 8th weekend,the three groups of treatment methods There was no significant difference in the control of positive symptoms(P>0.05).4 In the control of negative symptoms,the scores of the three groups of negative symptom scales were all reduced,and the differences within the group were statistically significant(P<0.05).The scores of the three groups were different at the end of the second week(P<0.05).There was no statistically significant difference between the three groups at the end of the 4th and the 8th weekend(P>0.05).5 In the statistical statistics of the general psychopathological scale,the scores of the control group were significantly lower than those of the other two groups by comparison,and the difference between the three groups was statistically significant(P<0.05).6 From the overall score of the PANSS scale and the general pathology scale,the data showed that the total scores of the three groups were significantly different at the end of the second week(P<0.01),and the total scores of the three groups at the fourth weekend were different,but the first There was no significant difference in the scores of the three groups at the end of the 8th week.The results showed no statistical significance(P>0.05).7 In the treatment of cognitive function,the cognitive function recovery scores of the three groups after treatment were significantly higher than the pre-treatment cognitive scores,especially in the olanzapine treatment group,the cognitive function improvement was more obvious(P<0.01).8 At the end of the second week,the Montreal Cognitive Assessment Scale scores were reduced,but at the 4th and 8th weekends,cognitive function improved and cognitive function recovery was higher than pre-treatment levels.From the total score of cognitive function,the olanzapine treatment group improved cognitive function,the difference was statistically significant(P<0.05).10 The results of the side-reaction survey showed that at the 2nd,4th,and 8th weekends,there was no statistically significant difference between the three groups in the TESS total group(P>0.05),but the TESS total at the 8th weekend.The differences were statistically significant(P<0.05).In the 11 groups,adverse reactions such as lethargy,constipation,weight gain,dry mouth and near memory impairment were observed.Among them,the risperidone treatment group compared with the other two groups.There was a higher probability of elevated serum prolactin levels(P<0.05),and the difference was statistically significant.The control group had a greater chance of extrapyramidal reaction,weight gain,headache,and constipation side effects than the other two groups.There was statistical significance(P<0.05),and there was no significant difference in other adverse reactions(P>0.05).Conclusions The treatment of olanzapine and risperidone in combination with MECT only has a better effect in controlling the symptoms of the general psychopathological scale,but the adverse reactions are significantly increased.From a clinical perspective,it is not recommended that these two drugs be combined with MECT treatment.The treatment of olanzapine or risperidone combined with MECT has an advantage in the treatment of patients with relapsed refractory schizophrenia and in the acute phase.The clinical treatment should be treated differently.Figure 1;Table12;Reference 165... |
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