| Objectives To evaluate the effectiveness and safety of Chaizhixiaopi Decoction,the clinical efficacy and recent recurrence rate of Chaizhixiaopi Decoction in the treatment of postprandial discomfort syndrome of liver-stomach disharmony were observed,and to provide more ideas and methods for clinical treatment of this disease.Methods In this study,a case-control study was conducted to collect 72 patients with postprandial discomfort syndrome of liver-stomach disharmony in the Department of Spleen-stomach Clinic of Shijiazhuang Traditional Chinese Medicine Hospital from January 2018 to April 2019.All the subjects were divided into treatment group and control group according to the order of visits,with 36 cases in each group.The treatment group was given a kind of traditional Chinese decoction named Chaizhixiaopi,and the control group was given a kind of Chinese patent medicine named WeiSu Granule.Every two weeks were one course of the treatment,and a total of four weeks of the treatment were observed.The changes of TCM symptom scores,FDDQL scores and gastric emptying rate before and after treatment in the two groups were recorded respectively,and electrocardiogram and indexes of liver and kidney function during medication were observed to evaluate the efficacy and safety of the drugs.Patients were followed up after two months of the end of treatment,and the TCM symptom scores of the effective patients were recorded again to understand the recent recurrence rate of patients,so as to comprehensively evaluate the clinical efficacy of Chaizhixiaopi Decoction.Finally,all the collected data were collate and analyzed by statistical software SPSS23.0.Results A total of 72 patients were enrolled in this clinical study,and 68 patients finally completed the clinical observation.There was no statistically significant difference in the distribution of gender,age,course of disease and degree of disease between the two groups(P > 0.05),which was comparable.1 Comparison of clinical efficacy:After 4 weeks of treatment,among the 34 patients in the treatment group,3 cases were cured,10 cases were markedly effective,18 cases were effective,3 cases were ineffective,and the total effective rate was 91.76%.Among the 34 patients in the control group,0 cases were cured.4 cases were markedly effective,23 cases were effective,and 7 cases were ineffective,and the total effective rate was 79.41%.The difference was statistically significant(P < 0.05)by rank sum test,indicating that the clinical effect of the treatment group was better than that of the control group.2 Comparison of total scores of TCM symptoms: After 2 and 4 weeks of treatment,the total score of TCM symptoms in both groups were lower than before(P < 0.05),indicating that both drugs can improve the clinical symptoms of patients.After 2 weeks of treatment,the total score of TCM symptoms in the treatment group(10.79±3.68)was lower than that in the control group(11.65±3.66),and the difference was not statistically significant(P > 0.05),indicating that the effect of the two drugs was similar.3 Comparison of single scores of TCM symptoms: After 2 and 4 weeks of treatment,the single integral of TCM symptoms in both groups were lower than before(P < 0.05).After 2 weeks of treatment,there was no significant difference in all symptoms between the two groups(P > 0.05).After 4 weeks of treatment,there was no significant difference between the two groups in the aspects of anorexia and acid regurgitation(P > 0.05),while in other aspects,the clinical effect of the treatment group was better than that of the control group(P < 0.05).4 Comparison of the quality of life: After 4 weeks of treatment,the FDDQL scores of the two groups were higher than those before treatment(P<0.05).The treatment group(88.93±6.19)was higher than that of the control group(83.51±6.52),and the difference was statistically significant,indicating the two drugs could improve the quality of daily life of patients,and the treatment effect of the treatment group was better than the control group(P<0.05).There was no significant difference in sleep and life between the two groups(P > 0.05),while in other aspects,the treatment effect of the treatment group was better than that of the control group(P < 0.05).5 Comparison of gastric emptying rate: After 4 weeks of treatment,the gastric emptying rate of the two groups were higher compared with before treatment(P < 0.05).The treatment group(72.35±15.53)was higher than the control group(65.15±16.03),and the difference was statistically significant,indicating that both drugs could promote gastric emptying,and the therapeutic effect was equivalent.6 Comparison of recurrence rate: In the follow-up 2 months after the end of treatment,the recurrence rate of the treatment group with 9.68% was lower than that of the control group with 33.33%,with statistically significant difference(P < 0.05),indicating that the long-term effect of the treatment group was better than that of the control group.7 Comparison of no adverse reactions: There were no any adverse reactions occurred in the two groups during the observation period.Conclusions Chaizhixiaopi Decoction can significantly improve the clinical symptoms and the quality of daily life of patients in the treatment of postprandial discomfort syndrome of liver-stomach disharmony,with low recurrence rate and no adverse reactions,which is worthy of clinical application.Figure1;Table12;Reference100... |
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