The Study Of Risk Factors Of Minor Stroke

Objective: Ischemic stroke can be classified into minor stroke and non-minor stroke according to the severity of the disease.Because the neurological defect symptoms of minor stroke(NIHSS?3)are mild,they are easy to be ignored by the public,and the incidence of stroke increases year by year.Hypertension and diabetes are recognized as risk factors for ischemic stroke,but whether the risk factors for minor stroke are specific is still inconclusive.This study explored the differences between risk factors for minor stroke and non-minor stroke,and provided a theoretical basis for the prevention and treatment of minor stroke.Methods: According to the diagnostic criteria of ischemic stroke,patients with ischemic stroke who were hospitalized in the Department of Neurology,Chifeng Hospital from December 2017 to November 2018 were consecutively included in chronological order.The 296 patients who met the inclusion criteria were scored and grouped using the National Institutes of Health Stroke Scale(NIHSS).The minor stroke group(NIHSS ? 3)had 182 patients,and the non-minor stroke group had(NIHSS>3)114 patients.We collected relevant clinical data of patients(such as age,gender,hypertension,coronary atherosclerotic heart disease,atrial fibrillation,diabetes,previous stroke history,etc.)and related tests(low-density lipoprotein cholesterol,high-density lipoprotein cholesterol,total cholesterol,triglycerides,fibrinogen,homocysteine,uric acid,cystatin C,etc.)and vascular examination.The risk factors and related laboratory indicators of the minor stroke group and the non-minor stroke group were analyzed by univariate analysis,and then multivariate logistic regression analysis was performed on the risk factors with statistically significant differences in the above analysis.Finally,the particularity of risk factors for minor stroke was discussed.Results:(1)There are no significant difference between the minor stroke group and the non-minor stroke group in age,hypertension,coronary atherosclerotic heart disease,atrial fibrillation,diabetes,smoking history,drinking history,previous stroke history,hyperuricemia,hyperhomocysteinemia,fibrinogen and cystatin C(P > 0.05).(2)The univariate analysis of risk factors in the two groups indicates that there are statistically significant differences in gender and hyperlipidemia between the minor stroke group and the non-minor stroke group(P < 0.05).The proportion of men and hyperlipidemia in the minor stroke group are higher than those in the non-minor stroke group.(3)The results of multivariate logistic regression analysis of risk factors in the two groups show that the risk of minor stroke in men is 2.216 times higher than that of non-minor stroke(OR = 2.216,95%CI: 1.321-3.716,P = 0.003),and the risk of minor stroke in patients with history of hyperlipidemia is 2.538 times higher than that of non-minor stroke(OR = 2.538,95%CI: 1.545-4.167,P = 0.001).(4)There are significant differences between the minor stroke group and the non-minor stroke group in mild intracranial stenosis,severe intracranial stenosis or occlusion,and mild extracranial stenosis(P<0.05).The proportion of mild intracranial artery stenosis,severe intracranial artery stenosis or occlusion,and mild extracranial artery stenosis in the minor stroke group are lower than those in the non-minor stroke group.Conclusion:(1)There are no significant differences between minor stroke and non-minor stroke in most risk factors such as hypertension,diabetes,coronary heart disease,hyperuricemia,smoking history,and drinking history,etc.(2)Compared with non-minor stroke,men and patients with hyperlipidemia are more likely to have minor stroke.(3)The incidence of mild stenosis of intracranial artery,severe stenosis or occlusion of intracranial artery and mild stenosis of extracranial artery in minor stroke are lower than those in non-minor stroke.