Association Between Cognition And Lipid Metabolism In Patients With First-episode Schizophrenia

Objective Nowadays,people pay more and more attention to mental diseases,especially schizophrenia,which cause heavy burden to society and family.At present,the etiology of schizophrenia is still unclear,and even with standardized treatment,it is difficult to fully recover all kinds of symptoms,especially cognitive impairment.Pathophysiological changes in patients with different subtypes may not be exactly the same,in this study,the first-episode schizophrenias were studied to explore the difference of cognitive function between patients with positive and negative symptoms and the correlation between cognitive function with lipid metabolism.The aim is to provide a reference for the diagnosis and treatment of cognitive disorders in schizophrenia patients with different symptom subtypes.Methods The first-episode schizophrenic patients were selected by strict criteria of admission and exclusion,and 85 first-episode schizophrenic patients were included in the study.Of these,70 cases completed all the research steps.First of all,all patients were assessed with positive and negative symptom scale(positive and negative syndrome scale,PANSS).The authors suggest that according to the scores of the PANSS positive subscale and the negative subscale,the patients can be divided into two types.70 patients were divided into two groups: 42 patients with positive symptoms and 28 patients with negative symptoms.All patients were assessed for cognitive function by the Chinese version of cognitive function test kit for schizophrenia the(Measurement and Treatment Research to Improve Congnition in Schizophrenia consensus cognitive battery,MCCB).The gross score of 9 sub-tests was converted to score.The characteristics of cognitive impairment between the patients with positive symptoms and those with negative symptoms were compared,and the differences in cognitive function between the two groups were compared.At the same time,the height and weight of the patients were recorded and the body mass index(BMI)was calculated.Blood samples were taken from the patients at 6: 00 a.m.on the second day of hospitalization.Determination of serum triglycerides,total cholesterol,low density lipoprotein and high density lipoprotein.According to the results of the above four lipid metabolism related indexes,the difference in lipid metabolism between the patients with negative symptoms and those with positive symptoms was compared.To analyze the relationship between lipid metabolism and cognitive function in schizophrenic patients with different symptoms.Results The cognitive impairment dimensions of patients with different symptoms are similar,but 6 of 9 subtests in MCCB had different levels of damage between the two groups(p < 0.05),including Trail Making Test(TMT),Brief assessment of cognition in schizophrenia-symbol encoding(BACS),Category Fluency,Hopkins Verbal Learning Test and Mazeand,Continuous Performance Test-identical pairs(CPT-IP),and the positive group had higher sores.In terms of BMI and lipid metabolism indicators,the total cholesterol and low-density lipoprotein levels in the negative group were higher than those in the positive group the difference was statistically significant(p < 0.05).The results of correlation analysis showed that there were negative correlation between the lipid indicators(total cholesterol andlow density lipoprotein)and cognition(TMT,BACS and CPT-IP)in negative group(p < 0.05).Conclusion : Patients with first-episode schizophrenia with positive and negative symptoms have similar lesion dimensions in cognitive function,but patients with negative symptoms are more severely impaired.There are differences in lipid metabolism between first-episode schizophrenia patients with positive dominant symptomsand negative dominant symptoms,and the lipid metabolism of first-episode schizophrenia patients with negative dominant symptoms is related to cognitive function.