Significance Of Serum KL-6 In Evaluating The Severity And Therapeutic Effect Of Patients With Connective Tissue Disease-related Interstitial Lung Disease Of Disease

Objective:1.To investigate the significance of serum KL-6 in the evaluation of severity of connective tissue disease-related interstitial lung disease(CTD-ILD)2.To explore the significance of serum KL-6 level in patients receiving hormone and immunosuppressive therapy for the evaluation of therapeutic effectMethod:1.59 patients,including 14 males and 45 females,who were treated in the second department of respiratory medicine of the second hospital of hebei medical university from January 2016 to December 2018 and were definitely diagnosed as CTD-ILD were collected.20 patients with sjogren syndrome,systemic sclerosis in 1 case,multiple myositis and dermatomyositis in 16 cases,11 cases of rheumatoid arthritis and other 11 cases,the determination of serum KL-6 level on admission to hospital,arterial blood oxygen partial pressure,6 minutes walking distance,pulmonary function index,high resolution computed tomography(HRCT)lung imaging data,and carries on the pattern and degree of HRCT abnormalities of visual inspection,pulmonary HRCT score calculation,analysis of the KL-6 the expression level of serum and lung function index,oxygenation index,6 minutes walking distance,the correlation of pulmonary HRCT score 2.The above 26 patients with CTD-ILD were treated with hormones and immunosuppressive agents and followed up for a long time.The serum KL-6 level,pulmonary function index and pulmonary HRCT score of these patients after 6 months were recorded,and the indexes of 26 patients with CTD-ILD before and after treatment were compared and analyzedResult:1.1 Serum KL-6 was detected again 6 months after the treatment with hormone and immunosuppressive drugs in 26 patients with CTD-ILD,and it was found that the serum KL-6 level after treatment(868.73±460.00)was decreased compared with that before treatment(1319.07±1169.64)(P<0.05),and the difference was statistically significant1.2 In 26 patients with CTD-ILD,High-Resolution Computed Tomography was performed again 6 months after steroid and immunosuppressive therapy,and the HRCT score after treatment(12.59±7.09)was significantly lower than that before treatment(19.05±11.22)(P<0.05),and the difference was statistically significant1.3 Nineteen out of 26 patients with CTD-ILD were treated with hormones and immunosuppressive agents for 6 months and completed lung function tests.there was no significant difference in FVC%predicted(85.94±23.61)before and after treatment compared with FVC%predicted(93.80±22.82)(P>0.05);there was no significant difference in TLC-SB%predicted(73.94±15.15)before and after treatment compared with TLC-SB%predicted(78.18±16.13)(P>0.05);there was no significant difference in DLco%predicted(61.50±16.55)before and after treatment compared with DLco%predicted(65.08±16.23)(P>0.05)2.1 There was a negative correlation between serum KL-6 expression and oxygenation index in patients with Connective Tissue Disease-associated Interstitial Lung Diseases(r=-0.631,P=0.000)2.2 There was a positive correlation between serum KL-6 expression level and HRCT score in the lungs of CTD-ILD-patients at admission(r=0.811,P=0.000)2.3 There was a negative correlation between serum KL-6 expression and FVC%predicted(r=-0.537,P=0.001),negative correlation with TLC-SB%predicted(r=-0.521,P=0.001),and negative correlation with DLco%predicted in patients with Connective Tissue Disease-associated Interstitial Lung Diseases(r=-0.399,P=0.013)2.4 There was a negative correlation between serum KL-6 expression level and 6-minute walking distance of CTD-ILD-patients at admission(r=-0.516,P=0.041)2.5 In 26 cases of CTD-ILD,High-Resolution Computed Tomography was performed again after 6 months of hormone and immunosuppressive treatment,and it was found that the serum KL-6 expression was positively correlated with HRCT score in the lungs(r=0.551,P=0.004)2.6 Nineteen out of 26 patients with CTD-ILD were treated with hormones and immunosuppressive agents for 6 months and completed lung function tests.The results showed that there was no significant correlation between serum KL-6 expression level and FVC%predicted(r=-0.322,P=0.223),TLC-SB%predicted(r=-0.425,P=0.070),DLco%predicted(r=-0.220,P=0.366)Conclusion:1.Serum KL-6 could reflect the severity of CTD-ILD in patients2.Serum KL-6 could evaluate the clinical therapeutic effect of CTD-ILD-patients...