Study Of Bcl-3 In Breast Cancer Cell Proliferation And Chemoresistance

Bcl-3 is an established oncogene in diverse malignant tumor.In this study,we investigate a dual role of Bcl-3 playing in BL1 subtype triple-negative breast cancer?TNBC?.The BL1 subtype TNBC is featured by increasing cell cycle gene expression and highest sensitivity to chemotherapy among the rest subtypes.Bcl-3 is associated with a better prognosis in BL1 patients.Highly expression of Bcl-3 in BL1 cell MDA-MB-468 promotes cell proliferation and induces the G₁/S transition by inhibiting p27and increase c-Myc and skp2 mRNA and protein level.Meanwhile,Bcl-3 enhances sensitivity of MDA-MB-468 to chemotherapeutics ABX and PTX.Furthermore,this regulation mechanisms is restricted in BL1 cell and not occurred in SUM159PT,a typical MSL subtype TNBC cell.Besides,Bcl-3 is ineffectual in MCF-7chemosensitivity,an ER⁺luminal type.These data suggest that Bcl-3 may be a potential clinical biomarker for diagnosis,treatment and prognosis of BL1 subtyped TNBC patients.