Risk Factors Of Catheter-Related Thrombosis In Breast Cancer Patients With Implantable Intravenous Port And Coping Strategies

Objective:To investigate the risk factors of catheter-related thrombosis(CRT)in breast cancer patients with implantable intravenous port and provide measures for early prevention.Methods:A total of 312 breast cancer patients who treat in the First Affiliated Hospital of Chongqing Medical University from January 2016 to September 2016 were recruited.Clinical data of the patients were retrospectively analyzed.Univariate analysis and multivariate Logistic regression analysis were used to analyze the risk factors of catheter-related thrombosis in breast cancer patients with implantable intravenous port,and the effect of Logistic regression model was evaluated by receiver operating characteristics(ROC)curve.Results:There were 193 cases with CRT in breast cancer patients with implantable intravenous port in 3 months,the incidence of CRT was 62%(193/312).Univariate analysis showed that age(x~2=8.502,P=0.014)and BMI(x~2=5.909;P=0.052)were associated with an increased risk of CRT.Prophylaxis with anticoagulant,systemic inflammation and surgery did not influence the occurrence of CRT between the two groups.In the multivariate analysis,41-60 years old[OR=2.3,95%CI(1.242~4.260),P=0.008],over the age of 60[OR=2.758,95%CI(1.232~6.174),P=0.014]and obesity[OR=2.611,95%CI(1.060~6.429),P=0.037]were independent risk factors for CRT.The ROC curve analysis showed area under curve of the Logistic regression model 0.618,95%CI(0.555~0.681),which demonstrated the specificity and sensitivity in predicting CRT were low.Conclusion:The incidence of CRT at early stage was relatively high in breast cancer patients with implantable intravenous port.Age and obesity were the independent risk factors for CRT.And there was no significant benefit to take prophylactic anticoagulant therapy.