Efficacy Of Ivabradine Versus Beta Blockers In Patients With Chronic Heart Failure:A Meta-Analysis

Objective:Aim to evaluate the efficacy of ivabradine versus beta blockers in chronic heart failure patients.Methods:A systematic electronic literature search for randomized controlled studies?RCTs?of ivabradine versus beta blockers in chronic heart failure patients was performed in CNKI?WANFANG?CBM?PubMed,Embase,Cochrane and other databases.The data of heart rate?HR?,6-minwalking test?6MWT?,maximal oxygen uptake?MVO₂?,left ventricular ejection fraction?LVEF?,left ventricular end diastolic diameter?LVEDD?,left ventricular end systolic diameter?LVESD?,brain natriuretic peptide?BNP?were pooled from the RCTs and analyzed by RevMan5.3.Results:A total of 692 chronic heart failure patients?NYHA?-??of5 RCTs were included.Ivabradine is superior to beta blockers in the reduction of HR?MD=-2.17,95%CI=-3.08^-1.26,P<0.001?,the improved of 6MWT?MD=38.73,95%CI=35.01⁴2.45,P<0.001?,the increased of LVEF?MD=1.32,95%CI=0.55².09,P=0.0008?,the reduction of BNP?MD=-62.5,95%CI=-104.20-20.80⁴2.45,P=0.003?,and the increased of MVO₂?MD=2.04,95%CI=0.28³.8,P=0.02?,but showed no statistically significant in LVESD and LVEDD between 2 groups.Conclusion:Ivabradine is superior to beta blockers in short-term clinical efficacy of HR,LVEF,MVO₂,6MWT and BNP for CHF patients.