The Clinical Significance Of Platelet Changes In Different Periods Of Kawasaki Disease

Objective:To explore the clinical significance of platelet(PLT)changes in acute and convalescent periods in Kawasaki disease(KD).Methods:The clinical data of children with KD from January 1,2016to December 31,2016 in Children’s Hospital of Chongqing Medical University were retrospectively collected.Through observing the change of the PLT,to explore its relevance to intravenous immunoglobulin(IVIG)unresponsiveness and coronary artery lesion(CAL)in acute period and guide the course of low-dose aspirin treatment in convalescent period of KD.Results:A total of 808 children with KD were analyzed.There were36 cases(4.46%)in IVIG unresponsive group and 772 cases(95.54%)in IVIG responsive group.Comparing with the IVIG responsive group,PLT and platelet crit(PCT)were lower,mean platelet volume(MPV)was higher in IVIG unresponsive group(P<0.05).There were 178 cases(22.03%)with CAL and 630 cases(77.97%)with no coronary artery lesion(nCAL)during convalescent period.Age and gender differences between the two groups were statistically significant(P<0.05).420 cases in nCAL group took low-dose aspirin regularly were followed up.PLT count in 321cases(76.43%)was lower than 400×10~9/L after six weeks,355 cases(84.52%)was lower than 400×109/L after 8 weeks,and it increased to 371cases(88.33%)after 12 weeks.There was no statistically significant difference between 8 weeks and 12 weeks(P=0.107).Conclusion:The change of PLT and its relative parameters PCT and MPV in acute period may be related to IVIG unresponsive KD.There was no significant correlation between PLT and CAL in KD.The appropriate course of low-dose aspirin treatment is 6~8 weeks for the most of KD children without coronary artery lesions or transient coronary artery lesions.