| Objective To observe the dynamic changes of serum Chemerin and Omentin-1 levels in patients with Acute Cerebral Infarction,and to explore its relationship with neurological deficits and prognosis in patients with Acute Cerebral Infarction.Methods A total of 109 patients with Acute Cerebral Infarction(ACI)hospitalized in our department of neurology from December 1,2017 to May 31,2018 were selected as the case group,and 114 persons without Acute Cerebral Infarction(N-ACI)who underwent stroke screening in our hospital served as the control group.According to whether the type 2 diabetes mellitus(T2DM)was combined,ACI combined with T2 DM group as group A(56 cases),ACI combined without T2 DM group as group B(53 cases),simple T2 DM group as group C(58 cases),and normal control Group as group D(56 cases).In the case group,according to the NIHSS score,20 patients in severe group(>15 points),45 patients in moderate group(5-15 points),44 patients in mild group(≤5 points);All patients with ACI were followde up for 90 days,and the prognosis was poor(mRS> 2)in 26 cases and the prognosis was good(mRS ≤2)in 83 cases.Serum Chemerin and Omentin-1 concentrations were measured by enzyme-linked immunosorbent assay(ELISA)in all patients(48 hours and 7days after ACI)and all control persons.The correlation between serum Chemerin,Omentin-1 levels and Acute Cerebral Infarction was analyzed.Results(1)The serum Chemerin level in the patients of ACI was significantly higher than that in the control group(P<0.01),the level of Omentin-1 was significantly lower than that in the control group(P<0.01).Compared with 48 hours after ACI,serum Chemerin levels were decreased and Omentin-1 levels were increased in the 7th day cases(P<0.01).(2)The case group was divided into NIHSS scores: the serum Chemerin levels of patients(48 hours and the 7th day after ACI)in different neurological deficits were as follows: severe group>moderate group>mild group,serum Omentin-1 levels: severe group<moderate group< mild group,the difference was statistically significant(P<0.05).Compared with the 48 hours,serum Chemerin levels were decreased and Omentin-1 levels were increased in the 7th day after ACI(P<0.01).(3)Pearson correlation analysis: Serum Chemerin levels were positively correlated with NIHSS scores both in 48 hours and the 7th day after ACI(r=0.806,P<0.01;r=0.749,P<0.01);Serum Omentin-1 levels were negatively correlated with NIHSS scores(r=-0.684,P<0.01;r=-0.588,P<0.01).(4)Compared with the good prognosis group,the serum of Chemerin was higher in the poor prognosis group,and the serum of Omentin-1 was lower in the poor prognosis group(P<0.05).(5)Logistic regression results showed that Chemerin was an independent risk factor for ACI,with an OR value of 1.48(95% CI: 1.127-1.943),Omentin-1 was a protective factor for ACI,with an OR value of 0.535(95%).CI: 0.324-0.844).Conclusions(1)Levels of serum Chemerin and Omentin-1 in the acute phase of Cerebral Infarction may be an evaluation index of neurological deficits and prognosis in Acute Cerebral Infarction.(2)Elevated serum Chemerin levels and decreased serum Omentin-1 levels are associated with Acute Cerebral Infarction.Combined detection of both concentrations probably become the biological indicators of Acute Cerebral Infarction.(3)Chemerin,Omentin-1 may affect the pathogenesis of Acute Cerebral Infarction by participating in blood glucose metabolism. |
