Studies On The Chemical Constituents And Bioactivities Of The Endophytic Fungus Phoma Multirostrata From Parasenecio Albus

This thesis comprises two parts.Chapter 1 presents the isolation,identification and cytotoxic activities of the secondary metabolites from the endophyte fungus Phoma multirostrata XJ-2-1 which was separated from Parasenecio albus.Chapter 2 is a review presenting new cytochalasans reported from 2015 to 2019.Thirteen new cytochalasins(1-13),eight known compounds(14-21)were isolated from the culture of Phoma multirostrata XJ-2-1,an endophytic fungus obtained from the medicinal plant Parasenecio albus.Their structures with absolute configurations were determined on the basis of comprehensive spectroscopic analysis including1D/2D NMR,HRESIMS,ECD and X-ray crystallography,combined with modified Mosher's method.All new compounds were evaluated for their cytotoxic activities against HepG2 human hepatocellular carcinoma,MCF-7 human breast adenocarcinoma,and CT26 murine colon carcinoma cell lines.