Effect Of Diverse Administration Routes On Opioid-induced Cough

[Background and Aims] Opioids are commonly used during the induction of modern general anesthesia.After intravenous administration of opioids,opioid-induced cough(OIC)is often observed.The aim of this study was to evaluate the effectiveness of altering the administration route of sulfentanyl.[Methods] According the design of a prospective blind randomized trial,a totally of 100 patients,with American Society of Anesthesiologists physical status Class I and II,scheduled for elective surgery which required central venous catheterization,were randomly assigned into two equally sized groups(n=50 in each),which were the central venous(CV)group and peripheral venous(PV)group.Before induction of general anesthesia,open both venous access regardless of the group assigned,16 gauge of single lumen central venous catheter and 18 guage of peripheral catheter were connected to all patients.Patients in both groups received 0.35ug/kg of sulfentanyl over 2 seconds through CV or PV access.The vital sign and occurrence frequency,time and intensity(0 for none,1-2 for mild,3-4 for moderate and 5 or above for severe)of cough were recorded within 1 minute by a nurse blinded to study design.1 minute after the opioid bolus,patiets' vital sign were recorded again,then propofol(1.5mg/kg),midazolam(0.05mg/kg)and rocuronium(0.9mg/kg)wereas administrated and the induction of general anesthesia was performed.Data analyzation were performed with Statistical Package for the Social Sciences(SPSS)version 19 using one-way ANOVA,independent t-test and Chi-Square test.Significance level was set at P<0.05.[Results] 99 patients were accomplished in the present trail while 1 patient was excluded on account of persistent smoking without quit before the surgery.There was no significant difference in hemodynamic value changes between patients in two groups(P>0.05).The cough frequency was 0.65 and 1.92 on average in CV Group and PV Group respectively(P < 0.05).There was no significant difference in the intensity(P>0.05)and occurrence time(P>0.05)of cough between 2 groups.[Conclusion] Opioids administered through central veins might reduce the occurrence of opioids induced cough without significant changes in hemodynamic status.Therefore the occurrence of adverse effects decreased and the safety of anesthesia induction increased.