| Heroin addiction has become a serious problem in the world,causing great harm to individuals,families and society.Nowadays,the diagnosis of heroin addiction is based on the experience of the doctor and the patient’s self-statement,which is lack of objective evaluation method index.Also there is no objective summary of whether the sex difference will affect heroin addiction.Therefore,it is very important to find an objective heroin-assisted diagnosis method.In this paper,we mainly analyzed the differences in characteristics between male heroin addicts and female heroin patients and their identical sex control subjects,as well as the abnormality of brain source.At the same time,the effect of gender difference between male and female on brain damage in heroin addicts was analyzed.The resting state EEG data in this paper were divided into four categories,including male class(20 heroin addicted men and 20 control men),female class(21 heroin addicted women and 21 control women),addicted class(26 heroin addicted men and 26 heroin addicted women)and control group(27 control male and 27 control women),all of the above subjects EEG data were collected in a quiet,enclosed room.Then,we calculated the average absolute power,power spectrum entropy and Rayleigh entropy of the five frequency bands,including Alpha1(7.5-10Hz),Alpha(10.5-13Hz),Beta1(13.5-18Hz),Beta2(18.5-21Hz)and Beta3(21.5-30Hz)and compared the differences.Meanwhile,abnormal brain source localization was performed in the four groups.The results showed that for the above three characteristics,the significant abnormalities in male class were appeared in the temporal and central regions of the Alpha1 and Alpha2 bands,and the Rayleigh entropy of the males in the parietal-occipital cortex of the Beta1 and Beta2 bands also showed significant differences.For the female class there was significant difference in the frontal region of the Beta1 band.Only the power spectrum entropy showed significant difference in the left central region of Alpha1 and Beta2 bands and the right occipital region of Alpha2 and Beta1 bands.The findings indicated that the central region and the occipital region of heroin addicts are important for studying brain damage in heroin addiction.In addition,the addicted class showed that the frontal region of Alpha1 and Beta3,the central region of the Alpha2 and Beta1 and the temporal region of Beta2 have significant differences.However,the control class showed that the significant differences are appeared in the frontal region of the Alpha1 and the central region of the Alpha2.The results suggested that the frontal area and the central region of the Alpha band are of great significance to study the differences between men and women.Subsequently,we used sLORETA for brain source localization and found that four types of localization common brain regions were located in the apical lobule,indicating that the apical lobule is an important brain region for studying heroin addiction and gender differences.Specifically,the male class had abnormalities in the brain areas of BA1,BA2,BA3,BA4,BA7,BA19,BA24,BA31 and BA40.The female class showed abnormality in BA7 and BA40.The addicted class had abnormal brain region in BA7,BA19,BA37,BA39 and BA40 of the Alpha2,in BA10,BA11,BA32 of beta3 and in BA10,BA11 of Gamma.And the control class located anomalies only in BA7.This suggests that the impact of gender differences needs to be considered in heroin addiction studies.Through the comparison of four kinds of resting-state EEG data,we found that there were significant differences in EEG characteristics and source localization between heroin addicts and normal controls.The methods,EEG feature analysis and source localization,could be used as an auxiliary diagnosis for heroin addiction and applied to the analysis of gender differences. |
PDF Full Text Request