Clinical Efficacy Of Ning Xin Chang Mai Yin In The Intervention Of Atrial Premature Beats With The Syndrome Of Blood Stasis Due To Qi Deficiency And Its Effect On P Wave Dispersion

ObjectiveBy observing the clinical efficacy of Ning Xin Chang Mai Yin in the treatment of atrial premature beats with the syndrome of blood stasis due to qi deficiency and its effect on P wave dispersion to evaluate the safety and effectiveness of Ning Xing Chang Mai Yin preliminarily.Methods100 atrial premature beats patients with the syndrome of blood stasis due to qi deficiency were randomly divided into the test group and the control group,each group with 50 cases of patients.The patients in the control group were treated by Metoprolol Succinate Sustained-release Tablets,while the experimental group was treated with Ning Xin Chang Mai Yin on the basis of the control group,all for 28 days.The researcher need to observe the changes of atrial premature beats frequency in 24 hours,TCM syndrome integral,the variation of heart rate,blood presure,blood,urine and stool routine,heptic and renal function before and after the treatment.Results1.Atrial premature beats frequency in 24 hours:Intra-group comparisons showed that 24 hours atrial premature beats frequency in the test group and the control group after treatment were significantly lower than that before treatment(P<0.01).There was a sharp difference in 24 hours atrial premature beats frequency after treatment between the treatment group and the control group(P<0.01),the decrease of 24 hours atrial premature beats frequency in the test group was more distinct than that in the control group.2.TCM syndrome integral:TCM syndrome integral of the treatment group and the control group both showed a dramatic decrease after treatment(P<0.01).There was a significant difference between the test group and the control group after trentment(P<0.01),the TCM syndrome integral of the test group declined more considerably than the of the control group.3.P wave dispersion:In comparision with pretherapy,P wave dispersion of the post treatment in the test group and the control group both showed a downward trend(P<0.01).There was a dramatic statistical significance in P wave dispersion distinction between the experimental group and the control group after treatment(P<0.01),P wave dispersion of the experimental group declined more significantly than that of the control group.4.Healing efficacy of atrial premature beats:The total effective rate of in the test group and the control group was 84.4% and 62.5% respectively,and there was a statistically significant difference between two groups(P<0.01),the clinical efficacy of the experimental group in the treatment of atrial premature beats patients with the syndrome of blood stasis due to qi deficiency was remarkably better than that of the control group.5.Curative effect of TCM syndrome integral:The total effective rate of in the test group and the control group was 88.9% and 60.4% respectively,and there was a statistically significant difference between two groups(P<0.01),the curative effect of the test group in the treatment of atrial premature beats patients with the syndrome of blood stasis due to qi deficiency was considerably better than that of the control group.6.Security index:The heart rate,blood presure of the test group and the control group remained stable during the whole treatment,and compared with pretherapy,there were no obvious abnormalities in blood,urine and stool routine,heptic and renal function in both groups after treatment.Conclusion1.Ning Xin Chang Mai Yin has definite curative effects on atrial premature beats patients with the syndrome of blood stasis due to qi deficiency,it can effectively improve the clinical symptoms and TCM syndrome integral,availably reduce 24 hours atrial premature beats frequency and P wave dispersion.2.Ning Xin Chang Mai Yin is safe to use in a short term.