The Relationship Between Glycated Albumin To Glycated Hemoglobin Ratio And Islet Function In Type 2 Diabetic Patients

Objective:To investigate the relationship between the ratio of glycated albumin to glycated hemoglobin and islet function in type 2 diabetic patients;Methods: A total of 518 patients with type 2 diabetes were enrolled,including 297 males and 221 females,with an average age of(54.04±11.91)years and an average duration of type 2 diabetes(5.99±5.97)years.After admission,the basic medical history was improved,and the general biochemical indicators and standard taro meal tests were completed the next day.Compare the correlation between GA/HbA1 c and the blood glucose-related indicators(FBG,1hBG,2hBG,ΔPG)and islet function related indicators(HOMA-β,HOMA-IR,FBCI,1hBCI,2hBCI,FINS,1hINS,2hINS)whether there are any difference;Results: The study found that GA/HbA1 c was significantly correlated with blood glucose and islet function.GA/HbA1 c was positively correlated with FBG、1hBG、2hBG andΔPG(r=0.373、0.308、0.397、0.284).As the increase of GA/HbA1 c ratio,the blood glucose monitoring index showed an increasing trend in four groups(P<0.001).There was a significant negative correlation between GA/HbA1 c and FINS,1hINS,2hINS,HOMA-β,FBCI,1hBCI,2hBCI(r=-0.213,-0.461,-0.406,-0.39,-0.348,-0.501,-0.438).With the increase of GA/HbA1 c,the islet secretion function decreased,but there was no significant correlation with HOMA-IR(P>0.05).Conclusion: The higher the level of GA/HbA1 c,the more severe the disorder of glucose metabolism,the worse the secretion function of islet β cells,but no significant correlation with insulin resistance.