Expressions Of TRPS1 In Epithelial Ovarian Cancer And Their Clinical Significance

Objective:To investigate the expression level of TRPS1 in epithelial ovarian tissues,to investigate their correlation in epithelial ovarian cancer,and to provide experimental bases for diagnosis and treatment of ovarian cancer.Methods:The expression of TRPS1 in 11 cases of normal ovarian tissues,21 cases of benign epithelial ovarian tumor tissues,28 cases of borderline epithelial ovarian tumor tissues and and 53 cases of epithelial ovarian cancer tissues,were detected by immunohistochemistry.And the different expression among those tissues and the correlation of TRPS1 expression with the clinical characteristics were analyzed.Kaplan-Meier method was utilized to analyze the correlation between TRPS1expression and prognosisResults:The expression of TRPS1 are rising gradually among normal epithelial ovarian tissues,benign epithelial ovarian tumor tissues,borderline epithelial ovarian tumor tissues and epithelial ovarian cancer tissues;the difference were statistically significant(benign epithelial ovarian tumor tissues vs.normal epithelial ovarian tissues,?~2=46.408,P<0.05;borderline epithelial ovarian tumor tissues vs.benign epithelial ovarian tumor tissues,?~2=15.091,P<0.05;epithelial ovarian cancer tissues vs.borderline epithelial ovarian tumor tissues,?~2=11.949,P<0.05).The expression of TRPS1 was related to lymph node metastasis(P<0.05),but age,patho-logical type,differentiation,tumor size and FIGO stage(P>0.05).Kaplan-Meier method revealed that patients with lower TRPS1expression had prolonged survival time than that with higher TRPS1 expression.Conclusions:High expressions of TRPS1 are involved in tumorigenesis and development of epithelial ovarian cancer,and their combined detection may assist in early diagnosis of pithelial ovarian cancer.