| Objective: This study evaluated the efficacy of Xiaohuan Decoction combined with quetiapine fumarate in the treatment of cognitive dysfunction in schizophrenia in order to improve the cognitive function of patients with schizophrenia and promote the recovery of their social functions,it provides possible treatment plans and ideas,and provides a basis for guiding clinical medication.Methods: A total of 23 inpatients with schizophrenia who met the inclusion criteria were selected and divided into a study group of 10 patients and a control group of 13 patients according to the random number table.The research group was given quetiapine fumarate combined with traditional Chinese medicine Xiaohuan Decoction as a treatment.The control group was given a single oral quetiapine fumarate as a treatment.The observation period of both groups was 8 weeks.Each patient was assessed weekly for Positive and Negative Syndrome Scale(PANSS scale)and Treatment Emergent Symptom Scale(TESS scale).The research group was given Abattery of computerized cognitive test(ACCT scales)at baseline and at the end of the week.During the observation period,indicators such as liver function,renal function,blood lipids,blood sugar,electrolytes,prolactin,and electrocardiogram were monitored.Results:(1)The PANSS scores of the study group were significantly lower than those of the control group at 6 weeks(64.10±7.64vs72.31±11.16)to 8 weekends(51.60±7.40vs63.23±7.08)(P<0.05),at the end of the 8th week,the reduction rate of the study group was higher than that of the control group(53.68%±7.96%vs45.60%±9.34%),and the proportion of significantly effective patients was also higher than that of the control group(70.00% vs 46.15%);(2)In the five-factor comparison of the PANSS scale,the significant difference between the two groups was the negative factor and the cognitive factor,but there was no significant difference in the single symptom improvement of the factor,the scores of the negative factors in the study group at the 5th week(2.36±0.49vs2.98±0.49)to 8 weeks(1.65±0.42vs2.38±0.43)were significantly lower than the control group(P<0.05),at 8 weeks(1.87±0.20 vs 2.12±0.27),the cognitive factor score was significantly lower than that of the control group(P<0.05);(3)The total score of the ACCT scale of the study group was significantly different before and after treatment(P<0.05),the numerical sequence(32.00±14.98vs40.00±17.40),Stroop color words(30.11±16.12vs42.22±16.22)and Stroop(26.00±17.54vs41.33±19.14)in the subtests were significantly different(P<0.05);(4)The combination of Xiaohuan Decoction did not increase the risk of adverse reactions.Conclusion:(1)The combination of Xiaohuan Decoction can significantly improve the effect of quetiapine in the treatment of schizophrenia;(2)The combination of Xiaohuan Decoction has a more significant therapeutic effect on negative factors and cognitive factors of schizophrenia;(3)The combination of Xiaohuan Decoction can improve the cognitive function of patients with schizophrenia,especially in the field of speech working memory and implementation inhibition;(4)The combination of Xiaohuan Decoction for the treatment of schizophrenia is safe. |
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