Clinical Pathology Characteristic And Survival Analysis Of Breast Cancer Patients With Different Hormone Receptor Status

Objective To investigate the clinicopathological characteristics,survival status and related risk factors affecting the prognosis of breast cancer patients with different hormone receptor status.Method The basic clinical data of 265 female breast cancer patients admitted to the Department of Mammary Surgery of the First Clinical Medical College of Lanzhou University from January2010 to December 2013 were collected.According to the different expression status of ER and PR,patients were divided into three groups,ER(+)/PR(+)group 126 cases,ER(+)/PR(-)54 cases and ER(-)/PR(-)88 cases.The clinical characteristics of age,BMI,menstrual status,tumor size,complications,preoperative lymph node enlargement,tissue type,histological grade,HER-2 status and lymph node metastasis between the three groups were analyzed.The basic clinical data of patients were consulted through electronic cases,and the 5-year survival of patients with different hormone receptor status was investigated by telephone follow-up.In this study,SPSS21.0software was used for data analysis.c~2 tests were used for comparison of counting data such as her-2 status and pathological type;Kruskal-Wallis H test was used for comparison of ranked date such as tumor size,histological grade and clinical stage;Kaplan-Meier was used for survival analysis of patients between different groups,and Log-rank method was used for comparison between groups.Cox model was used for multivariate survival analysis.Results 1.There were 265 patients in this study,126 cases(47.5%)in ER(+)/PR(+)group,54cases(20.4%)in ER(+)/PR(-)group,and 85 cases(32.1%)in ER(-)/PR(-)group.2.There were no significant differences in age,BMI,complications,preoperative lymph node enlargement,pathological type and tumor location among the three groups(P>0.05).3.The 5-year OS of ER(+)/PR(+)group,ER(+)/PR(-)group and ER(-)/PR(-)group were 95.2%,88.9%and 78.8%,respectively.There were significant differences in the 5-year OS among three groups(P=0.000).Pairwise comparison between the three groups show that the 5-year OS of ER(+)/PR(+)group was higher than that of ER(-)/PR(-)group,two groups of 5-year OS differences were statistically significant(P=0.000),while the 5-year OS of ER(+)/PR(+)and ER(+)/PR(-)group and ER(+)/PR(-)and ER(-)/PR(-)group had no significant difference(P>0.05).The 5-year DFS of the three groups were 92.1%,85.2%and 77.6%respectively,and the differences were statistically significant(P=0.000).The 5-year DFS of ER(+)/PR(+)group was higher than that of ER(-)/PR(-)group.The difference of 5-year DFS between ER(+)/PR(+)group and ER(-)/PR(-)group was statistically significant(P=0.000),but there were no significant differences in 5-year DFS between ER(+)/PR(+)and ER(+)/PR(-)group and ER(+)/PR(-)and ER(-)/PR(-)group(P>0.05).5.COX risk regression model showed that lymph node metastasis,histological grade and clinical stage were risk factors for prognosis.Conclusion(1)There were significant differences in menstrual status,tumor size,histological grade and HER-2 status among breast cancer patients with different hormone receptor status.(2)There were significant differences in 5-year overall survival and 5-year disease-free survival among three groups.The prognosis of ER(+)/PR(+)group was better than that of ER(-)/PR(-)group,but the prognosis of ER(+)/PR(-)group was not significantly different from that of the other two groups.(3)Lymph node metastasis,histological grade and clinical stage are risk factors affecting the prognosis of breast cancer.