The Relationship Between Obstructive Sleep Apnea Hypopnea Syndrome And Glaucoma

ObjectiveTo investigate the relationship between obstructive sleep apnea hypopnea syndrome(OSAHS)and glaucoma.Methods49 patients with OSAHS and 30 normal controls were enrolled.The control group was matched for age and sex.Intraocular pressure and visual field were detected in all the participants.Optical coherence tomography was used to evaluate the peripapillary retinal nerve fiber layer(RNFL),peripapillary and macular choroid,and optic nerve head topography for early detection of glaucoma.The correlation between RNFL thickness and the apnea hypopnea index(AHI)and minimum SaO2 in the OSAHS group was analyzed.Results1.Intraocular pressure,mean defect and pattern standard deviation were slmilar between groups(P>0.05).2.The vertical cup/disk ratio of the left and right eyes in the OSAHS group was(0.48±0.14)and(0.46±0.15)respectively.The cup volume of the left and right eyes in the OSAHS group was(0.1790±0.17)mm~3 and(0.1541±0.13)mm~3 respectively.Compared with individuals without OSAHS,vertical cup/disk ratio and cup volume were higher in the OSAHS group in both eyes,and the differences were statistically significant(P<0.05).Disc area,rim area and average cup/disc ratio were similar between patients with OSAHS and controls.3.The average RNFL thickness of the left and right eyes in the OSAHS group was(94.67±8.80)?m and(96.33±9.71)?m respectively.The temporal RNFL thickness of the left and right eyes in the OSAHS group was(71.17±14.86)?m and(76.94±17.03)?m respectively.The inferior RNFL thickness of the left and right eyes in the OSAHS group was(120.00±17.15)?m and(121.39±20.01)?m respectively.OSAHS patients showed significant reductions of the RNFL thickness in the average,inferior and temporal quadrants in both eyes compared with those values observed in the comparison group(P<0.05).No significant differences in nasal and superior quadrants were identified between both groups(P>0.05).4.The OSAHS group had significantly thinner choroidal thickness at 0.5mm?1.0mm?1.5mm and 2.0mm nasal and inferior to the fovea in both eyes than the control group(P<0.05).While subfoveal,superior and temporal choroidal thickness measurements did not differ significantly between groups(P>0.05).5.The peripapillary choroidal thickness were significantly thinner in the OSAHS group except for the nasal segments when compared with the controls.6.There was a statistically negative correlation between the average RNFL thickness and the AHI(r=-0.266,P=0.024)in the left eye of OSAHS patients.No significant correlation between different quadrant RNFL thickness and the minimum SaO2 was found.ConclusionsOSAHS patients exhibited partly decreased RNFL thickness and choroidal thickness,and increased cup volume parameters.RNFL thickness was correlated with AHI in the OSAHS group.These findings suggest that patients OSAHS are at increased risk for glaucoma.