The Mechanism Of Gastrointestinal Function On Postprandial Blood Glucose In Type 2 Diabetes Mellitus

With the prevalence of diabetes worldwide,the incidence of diabetes in China reached 11.6%.China is becoming the world's largest number of countries^[1].Unlike type 2 diabetic patients in western countries,49%of patients was characterized by postprandial hyperglycemia.Only 12%presented higher fasting glucose levels.Postprandial hyperglycemia become the main feature in the newly diagnosed type 2diabetes mellitus?T2DM?in China^[2].Due to the modern lifestyle,people spend 70%of the whole day in the postprandial or postprandial absorption state^[3].Moreover,postprandial glycemia was closely associated with macrovascular and microvascular complications.Therefore,studies on the pathogenesis and treatment of postprandial glucose are of great importance.Among all the factors,gastric emptying rate determines 35%of postprandial blood glucose fluctuation.Gastrointestinal hormones,such as glucagon like peptide-1,and intestinal glucose absorption play an important role in postprandial glycemia.Thus,strategies aiming at slowing gastric emptying,increasing GLP-1 secretion?the receptor agonists and analogues of GLP-1?,and reducing glucose absorption?SGLT-2 inhibitor?have become the new target for diabetes.Recent studies reported that sweet taste receptors in the bud have been found in the gastrointestinal tract.Sweet taste signaling pathway may be involved in regulation of gastric emptying,GLP-1 secretion and intestinal glucose absorption.In conclusion,to clarify the mechanism of sweet taste receptor and its signal transduction pathway regulating GLP-1 secretion and glucose absorption and its role in the pathogenesis of T2DM may provide a new intervention and target for the prevention of diabetes.