Clinical Analysis Of Reversible Splenial Lesion Syndrome In Children

Objective: To investigate the etiology and pathogenesis of reversible splenial lesion syndrome in children.Methods: 22 patients of reversible splenial lesion syndrome who were diagnosed and treated in the Pediatric Neurology Department,Shengjing Hospital of China Medical University during 2016.11-2019.2,were collected retrospectively.Results: Of the 22 children,12 were male and 10 were female.22 patients onsetted as gastrointestinal symptom(13 cases)or respiratory(7 case)symptom,in accompany with disturbance of consciousness(8 cases of drowsiness),convulsions(11 cases),headache(3case)as the main symptoms.Laboratory test showed the average blood sodium was(133.89±1.72)mmol/L.In etiology examination,8 cases showed human rotavirus antigen positive,and Mycoplasma pneumoniae antibody was found positive in 4 cases,Herpes simplex virus antibody was found positive in 2 cases,Coxsackie virus antibody was found positive in 3cases,eb virus antibody was found positive in 2 cases,Chlamydia pneumoniae antibody was found positive in 1 cases,Cytomegalovirus antibody was found positive in 2 cases,Respiratory syncytial virus antibody was found positive in 1cases,1 cases showed norovirus antigen positive.According to imaging,15 children were diagnosed RESLES-I with lesion only involving the splenium of the corpus callosum,7child was diagnosed RESLES-II with lesion extended from the splenium of the corpus callosum to the white matter of semi-oval.The lesion had completely disappeared in all children at follow-up MRI exams between 10 days and 6 month after the initial MRI.Conclusions: RESLES is a clinical-imaging syndrome,with acute onset,mild clinical symptoms,characteristic cranial MRI changes and good prognosis.