Syntheses Of TiO₂ Nanotube Arrays On Ti Filament And Properties Of Adsorption To ?2-MG In The Blood

Kidney is an important organ of human body its main function is excreting metabolites in human body and harmful and toxic substances in the blood.If the kidney disease,waste was accumulated in the body leading to disease.Large and medium toxin substances such as?2-microglobulin??2-MG?are produced by cells and aggregated in the body's blood,which can lead to various complications,such as dialysis related amyloidosis?DRA?.For this type of disease,common treatments include surgery and medication,but the side effects are large and the recurrence rates are high.Common blood purification methods can remove or reduce toxin molecules including?2-MG in the blood,but they can also eliminate beneficial molecules in the human body without selectivity in the process.In order to improve the selectivity of hemoperfusion materials,in this paper,additional single compact layer reinforced TiO₂ nanotube arrays were grown on Ti filament by anode oxidation method,then the surface of TiO₂ nanotube arrays were modified by amino,in order to use it as hemoperfusion absorbent.The results showed that the material not only ensured the specific adsorption of?2-MG,but also had little effect on the content of other proteins in the blood.?1?TiO₂ nanotube arrays were prepared by electrochemical anodic oxidation,and the combination of TiO₂ nanotube arrays with Ti substrates were improved by introducing an additional single compact layer.The harm of F element in TiO₂ nanotube arrays were reduced by calcination or cyclic releasing of F^-in deionized water.Through characterization and analysis,the single compact layer reinforced TiO₂ nanotube arrays with ordered morphology,strong combination and design of pore structures were obtained.?2?Anatase TiO₂ nanotube arrays with single compact layer were obtained by calcining.The adsorption capacity of single compact layer anatase TiO₂ nanotube arrays were improved by UV irradiation.As the reactant,surface amino modification was carried out.Through characterization and analysis,the single compact layer anatase TiO₂ nanotube arrays with ordered morphology,smaller pore size and clear visible pore structures,amino-functionalization were obtained.?3?In vitro adsorption properties of single compact layer anatase TiO₂ nanotube arrays with amino-functionalization were studied.It was mainly used to adsorb?2-MG in plasma and detected the adsorption amounts of the albumin and total protein.The adsorption rate was 92.86%,which was 43%and 49%higher than that of Ti filament and amino-functionalization Ti filament,respectively.At the same time,it had little effect on the adsorption of the albumin and total protein.