Comparative Analysis Of Clinicopathological Features Of Breast Ductal Carcinoma In Situ With Focal Invasive And Invasive Ductal Carcinoma

Objective:To compare the clinical and pathological features of ductal carcinoma in situ with focal invasive(DCIS-IDC)and invasive ductal carcinoma(IDC),to provide a reference for the diagnosis and treatment of this DCIS-IDC patient;and to follow up the two pathologies The prognostic characteristics of patients with type,try to explore the differences in biological behavior between the two pathological types.Method:Retrospective analysis of the case of DCIS-IDC and IDC after the first diagnosis of the Third Affiliated Hospital of Kunming Medical University from September 2012 to September 1818,and divided into:experimental group:DCIS-IDC patients;Group B:IDC patients.The ages,first diagnosis,menopausal status,B-ultrasound and mammography performance,tumor diameter,and lymphatic metastasis were compared.Follow-up data were collected and endpoint events were recorded.Statistical methods using SPSS 22.0 software,the measurement data obeys the normal distribution,described by X±S;the count data is analyzed by chi-square(?2),which is to explore the characteristics and distribution of DCIS-IDC indicators,as well as DCIS-IDC and IDC.Comparative analysis between the indicators;survival time was analyzed by Kaplan-Meier method;P<0.05 was statistically significant.Result:(1)There was no significant difference in age between the DCIS-IDC patients and the IDC patients(x2=1.853,P=0.607);(2).There was no significant difference in the initial symptoms between the two groups(x2=2.315,P=0.076);(3)There was a significant difference in the B-ultrasound between the DCIS-IDC group and the IDC group.Both groups showed B-ultrasound as:"The image of the tumor,the shape is irregular,the boundary is not clear,and the interior is hypoechoic.The distribution was uneven,the echo polymerization was enhanced,and the blood flow signal was observed in the mass and the periphery.The percentage of the description in the IDC group was higher than that in the DCIS-IDC group(x2=10.001,P=0.019).),The difference was statistically significant.(4)There were significant differences in the characteristics of molybdenum target between DCIS-IDC group and IDC group.The DCIS-IDC group and IDC group all showed the appearance of molybdenum target:"irregular mass or nodular shadow(or local abnormal gland area),the edge is blurred,the density is not uniform,the surrounding gland structure is disordered,there is malignant calcification,there are vascular shadows,and the blood vessels are increased and thickened,the percentage is the most;and DCIS-IDC is "irregular mass or nodular shadow(or local)The heterogland region),the edge is blurred,the density is not uniform,the surrounding gland structure is disordered,and the vascular shadow and vascular enlargement and thickening are the lowest;the IDC molybdenum target features "irregular mass or nodular shadow(or Local abnormal gland area),the edge is blurred,the density is not uniform,and the percentage of surrounding gland structure disorder is the least",(x2=57.933,P=0.000),the above difference is statistically significant;(5)There was no significant difference in menopause between the two groups(x2=2.477,P=0.116);(6)There was no significant difference in the size of the newly diagnosed tumor between the two groups(x2=4.979,P=0.083);(7)There were no significant differences in postoperative axillary lymph node metastasis between the patients(x2=5.868,P=0.053).(8)There was no significant difference in ER between the two groups(x2=0.008,P=0.929).(9)There was no significant difference in PR values between the two groups(x2=1.996,P=0.158).(10)CerB in the two groups of patients There was no significant difference between-B2(x2=1.214,P=0.750).(11)There was no significant difference in Ki-67 between the two groups(x2=3.776,P=0.052);(12).Number of relapses in DCIS-IDC group Accounted for 6.8%of the group;the number of relapses in the IDC group accounted for 9%of the group,the number of deaths in the DCIS-IDC group accounted for 4.9%of the number of cases,and the number of deaths in the IDC group accounted for the number of cases 6.0%.Kaplan-Meie survival analysis showed that the mean survival time of the DCIS-IDC group was 73.851 months and the IDC group was 63.096 months.The logistic curve of the two groups was tested by log-rank test.The results showed:?2=4.052,P=0.044<0.05;suggesting that the survival rate of patients in the DCIS-IDC group was higher than that in the IDC group at the same time point.Conclusions:There were no significant differences in the age of onset,initial symptoms,menopausal status,postoperative axillary lymph node metastasis,mass size and pathological parameters in patients with DCIS-IDC compared with IDC patients,but characteristic characteristics of B-ultrasound and mammography.The difference was statistically significant.The prognosis of DCIS-IDC patients may be better than that of IDC patients.