Influence Of Environmental Estrogens Bisphenol A On Female Reproductive Function

BackgroundAs a kind of phenolic environmental estrogens,Bisphenol A is widely used in the production of chemical products and daily necessities.In recent years,with the widely applica-tion of the plastic products and related industry,the application scope of BPA is increasing.BPA play an important role in influencing hormone's synthesis,secretion,transport,metab olism and clearance and its effects on female reproductive toxicity are manifold.Animal st-udies show that a certain concentration of BPA exposure is associated with polycystic ovary syndrome,endometriosis,and the occurrence of abortion.At home and abroad,toxicity stu-dies of Bisphenol A are based on animal experiments,and there is no report of Bisphenol A's toxic effects about crowd epidemiological investigation and human trials research.ObjectiveOur goals were to analysis daily exposure dosage BPA's effects on female reproductive function on the basis of describing women serum BPA level distribution.MethodsObjects of study were from these women who visited reproductive medicine clinic of Jinan central hospital from June 2014 to December 2015.We determined the target population by collecting history,consulting the outpatient records and Referring to artificial insem-ination medical records:(1)the healthy women;(2)women with growth disorder of follicle;(3)infertility;(4)women with polycystic ovary syndrome;(5)women with endometriosis;(6)women with recurrent spontaneous abortion.We compared the difference of the serum con-centration of BPA between every two groups.Due to the data do not accord with normal di-stribution,we selected the Mann-Whitney test method.The correlation between serum co-ncentration of BPA and age used the Spearman rank correlation test.We use IBM SPSS St-atistics 20.0 statistical software to analyze the data.ResultsThis study completed information records and blood samples of 268 subjects,includeing healthy women(n=48),women with growth disorder of follicle(n=24),infertility patients(n=61),patients with polycystic ovary syndrome(n=29),patients with endometriosis(n=27),patients with spontaneous abortion(n=79)(including patients with recurrent spontaneous abortion n=42,which is divided into closed antibody positive group(n=18)and closed antibody negative group(n=24)by enzyme-linked immunoassay method).The differences of Serum concentrations of BPA between healthy women and women with growth disorder of follicle,infertility,endometriosis and recurrent spontaneous abortion ha-d no statistical significance(P>0.05).Women with polycystic ovary syndrome have higher BPA concentrations than healthy women(P<0.05);In the history of spontaneous abortion in the crowd,women with closed antibody negatie have higher BPA concentrations than women with the closed antibody positive,which is significant(P<0.01).ConclusionsBy detecting the serum BPA levels of different target groups,this study found:1.The c-oncentration of BPA of patients with polycystic ovary syndrome was higher than the conc-entration of BPA of normal population,prompting BPA may be involved in the pathogens-is of polycystic ovary syndrome;2.In the crowd of spontaneous abortion,serum concentra-tions of BPA of women with blocking antibodies positive is significantly higher than the w-omen's with blocking antibodies negative,witch prompting BPA exposure maybe increased the risk of spontaneous abortion;3.By retrospectively analyzing the differences of different populations,serum concentrations of BPA,we concluded that BPA have a bad impact on f-emale reproductive function;4.This study can provide the basis for BPA's relationship with human reproductive health;5,By further health education was carried out on the target pop-ulation and reducing BPA,expose,we can gain prospective research results and provide fe-asible way to maintain and improve the human reproductive health.