| ObjectiveThis study aimed to demonstrate the accuracy of using prototype multi-inversion time arterial spin labeling?mTI-PASL?for the assessment of renal function and renal tumors,as well as the application of mTI-PASL in renal tumors been offered.MethodsThirty-five kidney donors were enrolled as the“healthy group”and twenty patients were used as the“patient group.”Conventional MR and ASL were collected on a MAGNETOM 3T MR scanner.All subjects in both the healthy and patient groups underwent the 99mTc-DTPA renal dynamic imaging exam for measuring GFR as the standard value of renal function.The Pearson correlation coefficients between RBF/BAT and GFR for the bilateral renal sides were calculated in both healthy and patient groups.In in healthy and patient groups,a two-sample t-test between the RBF/BAT value was performed to test the differences between tumor and healthy renal tissues.Resultsthe RBF of healthy subjects?right side:147±14 ml/100g/min,left side:141±13ml/100g/min?had a highly positive correlation?P<0.001?with GFR,while the BAT values?right side:382±21 ms,left side:384±33ms?had a negative correlation?P<0.001?with GFR.In patient group,the RBF and BAT value of each side were no significant correlation with GFR of the same side.In healthy group,the left and right side renal RBF and BAT value were not statistically significant?P>0.05?,In the patient group,the RBF?166±23 ml/100g/min?increased significantly?P<0.001?and BAT?375±25ms?was significantly shorter?P=0.016?in the T-side compared to the C-side(RBF 136±11ml·100g-1·min-1 BAT 401±38ms).ConclusionThe mTI ASL as a new preoperative routine examination method can assess renal function non-invasively in heathy renal donors.This may also provide a reference for the degree of renal tumor malignance and should be further investigated. |
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